医药前沿2024年1月第14卷第2期论著·11·胱抑素C联合D-二聚体检测对早期糖尿病肾病的诊断价值王虹（临沂市中医医院检验科山东临沂276000）【摘要】目的：研究胱抑素C（Cys-C）联合D-二聚体（D-D）检测对早期糖尿病肾病的诊断价值。方法：选取2022年1—12月临沂市中医医院收治的134例2型糖尿病患者作为试验组，并将其分为早期糖尿病肾病组（DN组）和单纯糖尿病组（DM组），另选择67名健康人作为对照组，比较三组Cys-C、D-D水平。绘制受试者工作特征（ROC）曲线，探究两个指标单一检测和联合检测对早期糖尿病肾病的诊断效能。结果：试验组Cys-C、D-D水平均高于对照组，DN组Cys-C、D-D水平均高于DM组，差异均有统计学意义（P＜0.05）。ROC曲线显示，Cys-C、D-D联合检测的曲线下面积（AUC）大于二者单独检测。结论：血清Cys-C、D-D水平联合诊断早期糖尿病肾病具有一定的价值，值得临床参考。【关键词】胱抑素C；D-二聚体；糖尿病肾病【中图分类号】R587.1【文献标识码】A【文章编号】2095-1752（2024）02-0011-03ThevalueofcystatinCandD-dimerinthediagnosisofearlydiabeticnephropathyWANGHongDepartmentofLaboratory,LinyiTraditionalChineseMedicineHospital,Linyi,Shandong276000,China【Abstract】ObjectiveTostudythediagnosticvalueofcystatinC(Cys-C)combinedwithD-dimer(D-D)inearlydiabetesnephropathy.Methods134patientswithtype2diabetesadmittedtoLinyiTraditionalChineseMedicineHospitalfromJanuarytoDecember2022wereselectedasthetestgroup,andtheyweredividedintoearlydiabetesnephropathygroup(DNgroup)andsimplediabetesgroup(DMgroup).Another67healthypeoplewereselectedasthecontrolgroup,andthelevelsofCys-CandD-Dinthetestgroupandthecontrolgroupwerecompared.Drawthereceiveroperatingcharacteristic(ROC)curve,andexplorethediagnosticefficacyofsingledetectionandjointdetectionoftwoindicatorsforearlydiabetesnephropathy.ResultsTheaveragelevelsofCys-CandD-Dlevelintheexperimentalgroupwerehigherthanthoseinthecontrolgroup,whiletheaveragelevelsofCys-CandD-DlevelintheDNgroupwerehigherthanthoseintheDMgroup,andthedifferenceswerestatisticallysignificant(P<0.05).TheROCcurveshowsthattheareaunderthecurveAUCforCys-CandD-Dcombineddetectionishigherthanthatforbothindividualdetection.Conclusions...
