论著复方甘草酸苷联合他克莫司治疗过敏性紫癜性肾炎患儿的临床效果张琼周芳∗郭亚菊(西安医学院第二附属医院,陕西西安７１００３８)[摘要]【目的】探讨复方甘草酸苷联合他克莫司治疗过敏性紫癜性肾炎患儿的临床效果.【方法】选择２０２０年１月至２０２３年１月本院收治的８８例过敏性紫癜性肾炎患儿,采用随机数字表法将其分为观察组与对照组,每组４４例.对照组采用复方甘草酸苷治疗,观察组采用复方甘草酸苷联合他克莫司治疗,两组治疗时间均为２个月.比较两组患儿肾功能指标[免疫球蛋白G(lgG)、免疫球蛋白A(lgA)]、炎症因子[白细胞介素Ｇ６(ILＧ６)、肿瘤坏死因子Ｇα(TNFＧα)]、氧化应激指标[丙二醛(MDA)、超氧化物歧化酶(SOD)]及不良反应发生情况.【结果】治疗后,两组lgG、lgA水平均低于治疗前,观察组低于对照组,差异有统计学意义(P＜０．０５);两组血清ILＧ６、TNFＧα水平低于治疗前,观察组低于对照组,差异有统计学意义(P＜０．０５).观察组患者临床有效率高于对照组,差异有统计学意义(P＜０．０５).观察组不良反应发生率低于对照组,差异有统计学意义(P＜０．０５).【结论】复方甘草酸苷联合他克莫司可改善过敏性紫癜性肾炎患儿肾功能,缓解炎症反应,临床治疗效果较好,且不良反应发生率低,值得推广与应用.[关键词]紫癜,过敏性/并发症;肾炎/并发症;甘草酸/药理学;他克莫司结合蛋白质类/药理学ClinicalEfficacyofCompoundGlycyrrhizicAcidGlycosideCombinedwithTacrolimusintheTreatmentofChildrenwithAllergicPurpuraNephritisZHANGQiong,ZHOUFang,GUOYaju(TheSecondAffiliatedHospitalofXi＇anMedicalCollege,Xi＇anShaanxi７１００３８)[Abstract]【Objective】Toexploretheclinicaleffectofcompoundglycyrrhizicacidglycosidecombinedwithtacrolimusinthetreatmentofchildrenwithallergicpurpuranephritis．【Methods】Atotalof８８childrenwithallergicpurpuranephritisadmittedtoourhospitalfromJanuary２０２０toJanuary２０２３wereselectedandranＧdomlydividedintoanobservationgroupandacontrolgroupusingarandomnumbertablemethod,with４４caＧsesineachgroup．Thecontrolgroupwastreatedwithcompoundglycyrrhizicacidglycoside,whiletheobserＧvationgroupwastreatedwithcompoundglycyrrhizicacidglycosidecombinedwithtacrolimus．Thetreatmenttimeforbothgroupswas２months．Twogroupsofchildrenwerecomparedintermsofrenalfu...
