·82·医药前沿2024年2月第14卷第4期临床医学负压创面治疗术辅助治疗深度烧伤的效果王薇茗，陈立发（扬州大学附属医院烧伤外科江苏扬州225000）【摘要】目的：探讨负压创面术在深度烧伤治疗中的辅助效果。方法：选取2021年10月—2023年4月在扬州大学附属医院接受治疗的63例深度烧伤患者作为研究对象，根据是否接受负压创面治疗术将患者分为观察组（n=30）和对照组（n=33）。两组均行削痂植皮治疗，观察组联用负压创面术，比较两组的治疗效果。结果：治疗后，观察组疼痛评分低于对照组，差异有统计学意义（P＜0.05）。治疗后，观察组的白细胞介素6、肿瘤坏死因子α和C反应蛋白水平均低于对照组，差异有统计学意义（P＜0.05）。观察组的创面愈合时间、肉芽生长时间和换药次数均低于对照组，差异有统计学意义（P＜0.05）。两组并发症发生率比较，差异无统计学意义（P＞0.05）。结论：在经削痂植皮术治疗深度烧伤的基础上联合采用负压创面术，能够更好改善患者的血清炎症因子水平，从而加快创面愈合。【关键词】深度烧伤；负压创面治疗；炎症因子；创面愈合【中图分类号】R644【文献标识码】A【文章编号】2095-1752（2024）04-0082-03TheeffectofnegativepressurewoundtherapyasanauxiliarytreatmentfordeepburnsWANGWeiming,CHENLifaDepartmentofBurnSurgery,AffiliatedHospitalofYangzhouUniversity,Yangzhou,Jiangsu225000,China【Abstract】ObjectiveToexploretheauxiliaryeffectofnegativepressurewoundtherapyinthetreatmentofdeepburns.Methods63patientswithdeepburnswhoreceivedtreatmentattheAffiliatedHospitalofYangzhouUniversityfromOctober2021toApril2023wereselectedasstudysubjects.Thepatientsweredividedintoobservationgroup(n=30)andcontrolgroup(n=33)accordingtowhethertheyreceivednegativepressurewoundtherapy.Bothgroupsweretreatedwithscabremovalandskingrafting,andtheobservationgroupwascombinedwithnegativepressurewoundtherapytocomparethetreatmenteffectsofthetwogroups.ResultsThepainscoreoftheobservationgroupaftertreatmentwaslowerthanthatofthecontrolgroup,andthedifferencewasstatisticallysignificant(P<0.05).Thelevelsofinterleukin6,tumornecrosisfactorαandC-reactiveproteinintheobservationgroupaftertreatmentwerelowerthanthoseinthecontrolgroup,andthedifferencewasstatisticallysignifica...
