胶质细胞在慢性应激诱发疼痛中的作用*陈菲1,魏思琪2,张琪1,曹东元2,△(1陕西中医药大学第二附属医院神经内科,咸阳712099;2陕西省颅颌面精准医学研究重点实验室,西安交通大学口腔医院,西安710004)摘要应激反应或疼痛的持续存在是机体对外界不良刺激反应的结果,最终导致健康受损。疼痛和应激反应相互影响,改变了机体的稳态。胶质细胞(glialcells)活化是慢性应激和慢性疼痛发生发展的共同病理基础。本文对胶质细胞在慢性应激和慢性疼痛间的关联作用及其机制研究进展进行综述。胶质细胞的激活是慢性应激诱发疼痛的主要特征和驱动因素之一,激活后的胶质细胞通过MAPK信号通路、趋化因子和炎性因子及相关受体等一系列机制诱发痛觉敏化,神经元-胶质细胞相互作用调节慢性应激诱发的疼痛。胶质细胞的生理和病理变化与一些慢性应激诱发的临床疾病的发生密切相关。关键词胶质细胞;慢性应激;疼痛;趋化因子;炎性因子中图分类号Q421;R402TheRoleofGlialCellsinChronicStress-InducedPain*CHENFei1,WEISi-Qi2,ZHANGQi1,CAODong-Yuan2,△(1DepartmentofNeurology,TheSecondAffiliatedHospital,ShaanxiU-niversityofTraditionalChineseMedicine,Xianyang712099,China;2KeyLaboratoryofShaanxiProvinceforCraniofacialPrecisionMedicineResearch,Xi’anJiaotongUniversityCollegeofStomatology,Xi’an710004,China)AbstractThepersistenceofstressresponsesorpainisaconsequenceofthebody'sreactiontoad-verseexternalstimuli,ultimatelyleadingtomaladaptation.Theinteractionsbetweenstressre-sponsesandpainchallengethebody’shomeostasis.Thereviewsummarizestheresearchprogressontheinterrelatedrolesandmechanismsofglialcellsinchronicstressandpain.Glialcellactiva-tionisoneofthemainfeaturesanddrivingfactorsofchronicstress-inducedpain.Activatedglialcellsareinvolvedinpainsensitizationthroughaseriesofmechanisms,includingtheMAPKsig-nalingpathway,chemokines,cytokines,andrelatedreceptors.Meanwhile,neuron-glialinterac-tionsregulatechronicstress-inducedpain.Thephysiologicalandpathologicalchangesinglialcellsarecloselyrelatedtotheonsetofsomediseasesinducedbychronicstress.Keywordsglialcell;chronicstress;pain;chemokine;cytokine引用格式:陈菲,魏思琪,张琪,曹东元.胶质细胞在慢性应激诱发疼痛中的作用.生理科学进展,2023,54(5...
