ActaOto-Laryngologica,2010;130:607–613ORIGINALARTICLESerialcytokinelevelsduringwoundhealinginrabbitmaxillarysinusmucosaXICAISUN,DEHUIWANG,HUAPENGYU&LIHUDepartmentofOtolaryngology,Eye,Ear,NoseandThroatHospital,ShanghaiMedicalCollege,FudanUniversity,Shanghai,ChinaAbstractConclusion:Collagendepositionwasincreasedinregenerativerabbitmaxillarymucosa,andtheelevatedcollagendepositionduringwoundhealingwasassociatedwithincreasedinterleukin(IL)-6andIL-8,anddecreasedIL-10.Objectives:Toobservethenaturalprogressionofwoundhealinginrabbitmaxillarysinusmucosaandtodetecttheexpressionofrelevantcytokines.Methods:Arabbitwound-healingmodelwasestablishedinthemaxillarysinus.Atdifferenttimesafterinjury,thesizesofmaxillaryostiawererecorded,andhistologicalchangesinthesinusmucosawereexaminedbymeansofhematoxylinandeosin(H&E)andMassontrichromestaining.Enzyme-linkedimmunosorbentassay(ELISA)wasusedtodetecttheconcentrationsofIL-6,IL-8,IL-10,andcollagentypesIandIII.Results:Alargeamountofimmaturespindledcollagendepositionwasobservedinthebasallaminaandlaminapropriaofregenerativemucosa.IL-6wasincreasedsignificantlyinregenerativemucosaafterinjury,especiallyat14dayspostwoundingwhencomparedwithnormalmucosa.IL-8wasalsoincreasedsignificantlyinregenerativemucosa;however,IL-10wasdecreasedsignificantlywhencomparedwithnormalmucosa.IL-6andIL-8showedasignificantcorrelationwiththeexpressionlevelofcollagentypeI.Keywords:Rabbitmodel,scarring,collagendeposition,inflammationIntroductionEndoscopicsinussurgery(ESS)hasbecomethestan-dardsurgicaltreatmentforchronicsinusitiswithorwithoutnasalpolypthatisresistanttomedicalman-agement.Althoughthefunctionalresultshavebeenextensivelydescribed,restenosisofsurgicalostiaandscarringofnasalcavityandsinusesafterESSarecom-mon.Adhesionformationasoneofformofscarringismostlyfoundintheanteriorethmoidregionbetweenthemiddleturbinateandthelateralnasalwall,rangingfrom1%to36%inincidence[1].Anotheranatomicstructurethatisoftenaffectedbyrestenosisisthefrontalostium.Ithasbeenreportedthattheave...
