SpringerSeriesinPharmaceuticalStatisticsGeraldineRauchSvenjaSchülerMeinhardKieserPlanningandAnalyzingClinicalTrialswithCompositeEndpointsSpringerSeriesinPharmaceuticalStatisticsEditorsF.BretzP.MüllerT.PermuttJ.PinheiroMoreinformationaboutthisseriesathttp://www.springer.com/series/15122GeraldineRauch•SvenjaSchRuler•MeinhardKieserPlanningandAnalyzingClinicalTrialswithCompositeEndpoints123GeraldineRauchInstituteofBiometryandClinicalEpidemiologyCharité-UniversitRatsmedizinBerlinBerlin,GermanySvenjaSchRulerInstituteofMedicalBiometryandInformaticsUniversityofHeidelbergHeidelberg,GermanyMeinhardKieserInstituteofMedicalBiometryandInformaticsUniversityofHeidelbergHeidelberg,GermanyISSN2366-8695ISSN2366-8709(electronic)SpringerSeriesinPharmaceuticalStatisticsISBN978-3-319-73769-0ISBN978-3-319-73770-6(eBook)https://doi.org/10.1007/978-3-319-73770-6LibraryofCongressControlNumber:2017964233MathematicsSubjectClassification(2010):62L05,62P10©SpringerInternationalPublishingAG,partofSpringerNature2017Thisworkissubjecttocopyright.AllrightsarereservedbythePublisher,whetherthewholeorpartofthematerialisconcerned,specificallytherightsoftranslation,reprinting,reuseofillustrations,recitation,broadcasting,reproductiononmicrofilmsorinanyotherphysicalway,andtransmissionorinformationstorageandretrieval,electronicadaptation,computersoftware,orbysimilarordissimilarmethodologynowknownorhereafterdeveloped.Theuseofgeneraldescriptivenames,registerednames,trademarks,servicemarks,etc.inthispublicationdoesnotimply,evenintheabsenceofaspecificstatement,thatsuchnamesareexemptfromtherelevantprotectivelawsandregulationsandthereforefreeforgeneraluse.Thepublisher,theauthorsandtheeditorsaresafetoassumethattheadviceandinformationinthisbookarebelievedtobetrueandaccurateatthedateofpublication.Neitherthepublishernortheauthorsortheeditorsgiveawarranty,expressorimplied,withrespecttothematerialcontainedhereinorforanyerrorsoromissionsthatmayhavebeenmade.Thepublisherremainsneutralwithregardtojurisdictionalclai...
