ClinicalTrialBiostatisticsandBiopharmaceuticalApplicationsEditedbyWalterR.YoungDing-Geng(Din)ChenClinicalTrialBiostatisticsandBiopharmaceuticalApplicationsClinicalTrialBiostatisticsandBiopharmaceuticalApplicationsEditedbyWalterR.YoungDing-Geng(Din)ChenCRCPressTaylor&FrancisGroup6000BrokenSoundParkwayNW,Suite300BocaRaton,FL33487-2742©2015byTaylor&FrancisGroup,LLCCRCPressisanimprintofTaylor&FrancisGroup,anInformabusinessNoclaimtooriginalU.S.GovernmentworksVersionDate:20141021InternationalStandardBookNumber-13:978-1-4822-1219-8(eBook-PDF)Thisbookcontainsinformationobtainedfromauthenticandhighlyregardedsources.Reasonableeffortshavebeenmadetopublishreliabledataandinformation,buttheauthorandpublishercannotassumeresponsibilityforthevalidityofallmaterialsortheconsequencesoftheiruse.Theauthorsandpublishershaveattemptedtotracethecopyrightholdersofallmaterialreproducedinthispublicationandapologizetocopyrightholdersifpermissiontopublishinthisformhasnotbeenobtained.Ifanycopyrightmaterialhasnotbeenacknowledgedpleasewriteandletusknowsowemayrectifyinanyfuturereprint.ExceptaspermittedunderU.S.CopyrightLaw,nopartofthisbookmaybereprinted,reproduced,transmit-ted,orutilizedinanyformbyanyelectronic,mechanical,orothermeans,nowknownorhereafterinvented,includingphotocopying,microfilming,andrecording,orinanyinformationstorageorretrievalsystem,withoutwrittenpermissionfromthepublishers.Forpermissiontophotocopyorusematerialelectronicallyfromthiswork,pleaseaccesswww.copyright.com(http://www.copyright.com/)orcontacttheCopyrightClearanceCenter,Inc.(CCC),222RosewoodDrive,Danvers,MA01923,978-750-8400.CCCisanot-for-profitorganizationthatprovideslicensesandregistrationforavarietyofusers.FororganizationsthathavebeengrantedaphotocopylicensebytheCCC,aseparatesystemofpaymenthasbeenarranged.TrademarkNotice:Productorcorporatenamesmaybetrademarksorregisteredtrademarks,andareusedonlyforidentificationandexplanationwithoutintenttoinfringe.VisittheTaylor&FrancisWebsiteathttp://www.taylorandfrancis.comandtheC...
