MethodsandApplicationsofStatisticsinClinicalTrialsVolume1WILEYSERIESINMETHODSANDAPPLICATIONSOFSTATISTICSAdvisoryEditorN.BalakrishnanMcMasterUniversity,CanadaTheWileySeriesinMethodsandApplicationsofStatisticsisauniquegroupingofresearchthatfeaturesclassiccontributionsfromWiley'sEncyclopediaofStatisticalSciences,SecondEdition(ESS,2e)alongsidenewlywrittenarticlesthatexplorevariousproblemsofinterestandtheirintrin-sicconnectiontostatistics.Thegoalofthiscollectionistoencompassanencyclopedicscopeofcoveragewithinindividualbooksthatunifythemostimportantandinterestingapplicationsofsta-tisticswithinaspecificfieldofstudy.EachbookintheseriessuccessfullyupholdsthegoalsofESS,2ebycombiningestablishedliteratureandnewlydevelopedcontributionswrittenbyleadingacademics,researchers,andpractitionersinacomprehensiveandaccessibleformat.Theresultisasuccinctreferencethatunveilsmodern,cutting-edgeapproachestoacquiring,analyzing,andpre-sentingdataacrossdiversesubjectareas.WILEYSERIESINMETHODSANDAPPLICATIONSOFSTATISTICSBalakrishnan·MethodsandApplicationsofStatisticsintheLifeandHealthSciencesBalakrishnan·MethodsandApplicationsofStatisticsinBusiness,Finance,andManagementScienceBalakrishnan·MethodsandApplicationsofStatisticsinEngineering,QualityControl,andthePhysicalSciencesBalakrishnan·MethodsandApplicationsofStatisticsintheSocialandBehavioralSciencesBalakrishnan·MethodsandApplicationsofStatisticsintheAtmosphericandEarthSciencesBalakrishnan·MethodsandApplicationsofStatisticsinClinicalTrials,Volume1:Concepts,Principles,Trials,andDesignsBalakrishnan·MethodsandApplicationsofStatisticsinClinicalTrials,Volume2:Planning,Analysis,andInferentialMethodsMethodsandApplicationsofStatisticsinClinicalTrialsVolume1Concepts,Principles,Trials,andDesignEditedbyN.BalakrishnanMcMasterUniversityDepartmentofMathematicsandStatisticsHamilton,Ontario,CanadaWILEYCopyright©2014byJohnWiley&Sons,Inc.Allrightsreserved.PublishedbyJohnWiley&Sons,Inc.,Hoboken,NewJersey.Allrightsreserved.PublishedsimultaneouslyinCanada.N...
