AppliedBioinformaticsandBiostatisticsinCancerResearchSerieseditors:JeanneKowalski,StevenPiantadosiForfurthervolumes:http://www.springer.com/series/7616WanTang•XinTuEditorsModernClinicalTrialAnalysis123EditorsWanTangDepartmentofBiostatisticsandComputationalBiologySchoolofMedicineandDentistryUniversityofRochesterElmwoodAve.601Rochester,NewYork,USAXinTuDepartmentofBiostatisticsandComputationalBiologySchoolofMedicineandDentistryUniversityofRochesterElmwoodAve.601Rochester,NewYork,USAISBN978-1-4614-4321-6ISBN978-1-4614-4322-3(eBook)DOI10.1007/978-1-4614-4322-3SpringerNewYorkHeidelbergDordrechtLondonLibraryofCongressControlNumber:2012943945©SpringerScience+BusinessMediaNewYork2013Thisworkissubjecttocopyright.AllrightsarereservedbythePublisher,whetherthewholeorpartofthematerialisconcerned,specificallytherightsoftranslation,reprinting,reuseofillustrations,recitation,broadcasting,reproductiononmicrofilmsorinanyotherphysicalway,andtransmissionorinformationstorageandretrieval,electronicadaptation,computersoftware,orbysimilarordissimilarmethodologynowknownorhereafterdeveloped.Exemptedfromthislegalreservationarebriefexcerptsinconnectionwithreviewsorscholarlyanalysisormaterialsuppliedspecificallyforthepurposeofbeingenteredandexecutedonacomputersystem,forexclusiveusebythepurchaserofthework.DuplicationofthispublicationorpartsthereofispermittedonlyundertheprovisionsoftheCopyrightLawofthePublisher’slocation,initscurrentversion,andpermissionforusemustalwaysbeobtainedfromSpringer.PermissionsforusemaybeobtainedthroughRightsLinkattheCopyrightClearanceCenter.ViolationsareliabletoprosecutionundertherespectiveCopyrightLaw.Theuseofgeneraldescriptivenames,registerednames,trademarks,servicemarks,etc.inthispublicationdoesnotimply,evenintheabsenceofaspecificstatement,thatsuchnamesareexemptfromtherelevantprotectivelawsandregulationsandthereforefreeforgeneraluse.Whiletheadviceandinformationinthisbookarebelievedtobetrueandaccurateatthedateofpublication,neithertheauthorsnortheeditorsnorthepubl...
