ClinicaltrialsinolderadultsClinicaltrialsinolderadultsEDITEDBYAntonioCherubiniGeriatricsandGeriatricEmergencyCareIRCCS‐INRCAAncona,ItalyRobertoBernabeiDepartmentofGeriatrics,NeuroscienceandOrthopedicsCatholicUniversityofSacredHeartRome,ItalyLuigiFerrucciNationalInstituteonAgingBaltimore,MD,USANiccolòMarchionniDepartmentofCriticalCareMedicineandSurgeryUnitofGerontologyandGeriatricMedicineUniversityofFlorenceandAziendaOspedaliero‐UniversitariaCareggiFlorence,ItalyStephanieStudenskiDivisionofGeriatricMedicine,UniversityofPittsburghSchoolofMedicine;ClaudeD.PepperOlderAmericansIndependenceCenterattheUniversityofPittsburghandVAPittsburghGRECCPittsburgh,Pennsylvania,USABrunoVellasAlzheimer’sDiseaseClinicalResearchCentre,GérontopôleToulouseUniversityHospitalToulouse,FranceThiseditionfirstpublished2015©2015byJohnWiley&Sons,LtdRegisteredOfficeJohnWiley&Sons,Ltd,TheAtrium,SouthernGate,Chichester,WestSussex,PO198SQ,UKEditorialOffices9600GarsingtonRoad,Oxford,OX42DQ,UKTheAtrium,SouthernGate,Chichester,WestSussex,PO198SQ,UK111RiverStreet,Hoboken,NJ07030‐5774,USAFordetailsofourglobaleditorialoffices,forcustomerservicesandforinformationabouthowtoapplyforpermissiontoreusethecopyrightmaterialinthisbookpleaseseeourwebsiteatwww.wiley.com/wiley-blackwellTherightoftheauthortobeidentifiedastheauthorofthisworkhasbeenassertedinaccordancewiththeUKCopyright,DesignsandPatentsAct1988.Allrightsreserved.Nopartofthispublicationmaybereproduced,storedinaretrievalsystem,ortransmitted,inanyformorbyanymeans,electronic,mechanical,photocopying,recordingorotherwise,exceptaspermittedbytheUKCopyright,DesignsandPatentsAct1988,withoutthepriorpermissionofthepublisher.Designationsusedbycompaniestodistinguishtheirproductsareoftenclaimedastrademarks.Allbrandnamesandproductnamesusedinthisbookaretradenames,servicemarks,trademarksorregisteredtrademarksoftheirrespectiveowners.Thepublisherisnotassociatedwithanyproductorvendormentionedinthisbook.Itissoldontheunderstandingthatthepublisherisnotengagedinrenderi...