GLOBALCLINICALTRIALSFORALZHEIMER’SDISEASEDesign,Implementation,andStandardizationEditedbyMenghisBairu,mdPresidentandChiefExecutiveOfficerSperanzaTherapeuticsCorp,Dublin,IrelandChiefMedicalOfficerandHeadofGlobalDevelopmentElanPharmaceuticalsCambridge,Massachusetts,USAMichaelW.Weiner,mdDirectoroftheMagneticResonanceUnitattheVAMedicalCenterProfessorofRadiology,Medicine,PsychiatryandNeurologyUniversityofCaliforniaatSanFrancisco,SchoolofMedicineSanFrancisco,California,USAAMSTERDAM•BOSTON•HEIDELBERG•LONDONNEWYORK•OXFORD•PARIS•SANDIEGOSANFRANCISCO•SINGAPORE•SYDNEY•TOKYOAcademicPressisanimprintofElsevierAcademicPressisanimprintofElsevier525BStreet,Suite1800,SanDiego,CA92101-4495,USA32JamestownRoad,LondonNW17BY,UK225WymanStreet,Waltham,MA02451,USACopyright©2014ElsevierInc.Allrightsreserved.Nopartofthispublicationmaybereproduced,storedinaretrievalsystem,ortransmittedinanyformorbyanymeanselectronic,mechanical,photocopying,recordingorotherwisewithoutthepriorwrittenpermissionofthepublisher.PermissionsmaybesoughtdirectlyfromElsevier’sScience&TechnologyRights,DepartmentinOxford,UK:phone(+44)(0)1865843830;fax(+44)(0)1865853333;email:permissions@elsevier.com.Alternatively,visittheScienceandTechnologyBookswebsiteatwww.elsevierdirect.com/rightsforfurtherinformation.BritishLibraryCataloguing-in-PublicationDataAcataloguerecordforthisbookisavailablefromtheBritishLibraryLibraryofCongressCataloging-in-PublicationDataAcatalogrecordforthisbookisavailablefromtheLibraryofCongressISBN:978-0-12-411464-7NoticeNoresponsibilityisassumedbythepublisherforanyinjuryand/ordamagetopersons,orpropertyasamatterofproductsliability,negligenceorotherwise,orfromanyuseor,operationofanymethods,products,instructionsorideascontainedinthematerialherein.Becauseofrapidadvancesinthemedicalsciences,inparticular,independentverificationofdiagnosesanddrugdosagesshouldbemade.ForinformationonallAcademicPresspublicationsvisitourwebsiteatelsevierdirect.comPrintedandboundintheUnitedStatesofAmerica1415161718109876...
