ClinicalTrialsinRheumatologyRüdigerMüller•JohannesvonKempisClinicalTrialsinRheumatologyAuthorsRüdigerMüllerDivisionofRheumatologyandRehabilitationDepartmentofInternalMedicineKantonsspitalSt.GallenSwitzerlandJohannesvonKempisDivisionofRheumatologyandRehabilitationDepartmentofInternalMedicineKantonsspitalSt.GallenSwitzerlandISBN978-1-84996-383-1e-ISBN978-1-84996-384-8DOI10.1007/978-1-84996-384-8SpringerLondonDordrechtHeidelbergNewYorkBritishLibraryCataloguinginPublicationDataAcataloguerecordforthisbookisavailablefromtheBritishLibraryLibraryofCongressControlNumber:2010937971©Springer-VerlagLondonLimited2011Apartfromanyfairdealingforthepurposesofresearchorprivatestudy,orcriticismorreview,aspermit-tedundertheCopyright,DesignsandPatentsAct1988,thispublicationmayonlybereproduced,storedortransmitted,inanyformorbyanymeans,withthepriorpermissioninwritingofthepublishers,orinthecaseofreprographicreproductioninaccordancewiththetermsoflicensesissuedbytheCopyrightLicensingAgency.Enquiriesconcerningreproductionoutsidethosetermsshouldbesenttothepublishers.Theuseofregisterednames,trademarks,etc.,inthispublicationdoesnotimply,evenintheabsenceofaspecificstatement,thatsuchnamesareexemptfromtherelevantlawsandregulationsandthereforefreeforgeneraluse.Productliability:Thepublishercangivenoguaranteeforinformationaboutdrugdosageandapplicationthereofcontainedinthisbook.Ineveryindividualcasetherespectiveusermustcheckitsaccuracybyconsultingotherpharmaceuticalliterature.Coverdesign:eStudioCalamar,Figueres/BerlinPrintedonacid-freepaperSpringerispartofSpringerScience+BusinessMedia(www.springer.com)Toourwives,andchildren:Sophia,andFranziska,Alexandra,Johanna,Antonius,HelenaJohannesvonKempisElke,andIsmene,FrederikandMostafaFarmand,whowasaninspirationtomeduringmedicalschoolRüdigerMüllerviiForewordOverthepast20years,rheumatologistshavedevelopedandwitnessedmanyparadigmaticchangesnotonlyinthemedicationofrheumatoidarthritis(RA)butalsoinotherautoim-munerheumaticdiseases.WithregardtoRA,lessjointd...
