1FAX:+81-22-717-8185AUTHORS’RESPONSIBILITYFORMTohokuJournalofExperimentalMedicine(TJEM)Whensubmittingarevisedmanuscript,thecorrespondingauthorisrequiredtosubmitthecopyofthecompletedAuthors’ResponsibilityFormtotheEditorialOfficebyFAX(+81-22-717-8185)ore-mail(office@journal.med.tohoku.ac.jp).EachauthormustreadthestatementofAuthors’Responsibilityandsignonthisform.Authors’ResponsibilityEachauthorshouldreadbelowstatementsandsigntoagreethat:1)Thecontentshavenotbeenpublishedelsewhere.2)Themanuscriptisnotunderconsiderationforpublicationelsewhere.3)Allauthorstooksubstantialcontributiontoconceptionsanddesign,executionoranalysisandinterpretationofdata.4)Allauthorstooksubstantialcontributiontodraftingthearticleorrevisingitforimportantintellectualcontent.5)Allauthorshavegivenfinalapprovalofthesubmittedmanuscript.6)Scientificinvestigationsinvolvinghumansubjects,experimentsareperformedinaccordancewiththeethicalstandardsformulatedintheHelsinkiDeclarationof1964.7)Animalexperimentsshouldfollowtheethicalstandards,andmeasurestakentoprotectanimalsfrompainordiscomfortshouldbementioned.ManuscriptID:TJEM-20Iagreetotheauthors’responsibilitystatement.Printedname:Date:Signature:Printedname:Date:Signature:Printedname:Date:Signature:Printedname:Date:Signature:2AUTHORS’RESPONSIBILITYFORM(Continued)ManuscriptID:TJEM-20Printedname:Date:Signature:Printedname:Date:Signature:Printedname:Date:Signature:Printedname:Date:Signature:Printedname:Date:Signature:Printedname:Date:Signature:Printedname:Date:Signature:Printedname:Date:Signature:Printedname:Date:Signature:Printedname:Date:Signature:Printedname:Date:Signature:Printedname:Date:Signature: