Sin-HoJungRandomizedPhaseIICancerClinicalTrialsCRCPressTaylor&FrancisGroup6000BrokenSoundParkwayNW,Suite300BocaRaton,FL33487-2742©2013byTaylor&FrancisGroup,LLCCRCPressisanimprintofTaylor&FrancisGroup,anInformabusinessNoclaimtooriginalU.S.GovernmentworksVersionDate:20130315InternationalStandardBookNumber-13:978-1-4398-7186-7(eBook-PDF)Thisbookcontainsinformationobtainedfromauthenticandhighlyregardedsources.Reasonableeffortshavebeenmadetopublishreliabledataandinformation,buttheauthorandpublishercannotassumeresponsibilityforthevalidityofallmaterialsortheconsequencesoftheiruse.Theauthorsandpublishershaveattemptedtotracethecopyrightholdersofallmaterialreproducedinthispublicationandapologizetocopyrightholdersifpermissiontopublishinthisformhasnotbeenobtained.Ifanycopyrightmaterialhasnotbeenacknowledgedpleasewriteandletusknowsowemayrectifyinanyfuturereprint.ExceptaspermittedunderU.S.CopyrightLaw,nopartofthisbookmaybereprinted,reproduced,transmitted,orutilizedinanyformbyanyelectronic,mechanical,orothermeans,nowknownorhereafterinvented,includingphotocopying,microfilming,andrecording,orinanyinformationstor-ageorretrievalsystem,withoutwrittenpermissionfromthepublishers.Forpermissiontophotocopyorusematerialelectronicallyfromthiswork,pleaseaccesswww.copy-right.com(http://www.copyright.com/)orcontacttheCopyrightClearanceCenter,Inc.(CCC),222RosewoodDrive,Danvers,MA01923,978-750-8400.CCCisanot-for-profitorganizationthatpro-videslicensesandregistrationforavarietyofusers.Fororganizationsthathavebeengrantedapho-tocopylicensebytheCCC,aseparatesystemofpaymenthasbeenarranged.TrademarkNotice:Productorcorporatenamesmaybetrademarksorregisteredtrademarks,andareusedonlyforidentificationandexplanationwithoutintenttoinfringe.VisittheTaylor&FrancisWebsiteathttp://www.taylorandfrancis.comandtheCRCPressWebsiteathttp://www.crcpress.comContentsPrefacexiii1Introduction12Single-ArmPhaseIITrialDesigns52.1Single-StageDesigns...........................................52.1.1DesignofSingle-StagePhaseIIT...
