ClinicalTrialDesignChallengesinMoodDisordersClinicalTrialDesignChallengesinMoodDisordersEditedbyMauricioTohenUniversityofNewMexicoHealthSciencesCenterAlbuquerque,NM,USACharlesL.BowdenUniversityofTexasHealthScienceCenteratSanAntonioSanAntonio,TX,USAAndrewA.NierenbergMassachusettsGeneralHospital;HarvardMedicalSchoolBoston,MA,USAJohnR.GeddesUniversityofOxford,Oxford,UKAMSTERDAM•BOSTON•HEIDELBERG•LONDONNEWYORK•OXFORD•PARIS•SANDIEGOSANFRANCISCO•SINGAPORE•SYDNEY•TOKYOAcademicPressisanimprintofElsevierAcademicPressisanimprintofElsevier32JamestownRoad,LondonNW17BY,UK525BStreet,Suite1800,SanDiego,CA92101-4495,USA225WymanStreet,Waltham,MA02451,USATheBoulevard,LangfordLane,Kidlington,OxfordOX51GB,UK©2015ElsevierInc.Allrightsreserved.Nopartofthispublicationmaybereproducedortransmittedinanyformorbyanymeans,electronicormechanical,includingphotocopying,recording,oranyinformationstorageandretrievalsystem,withoutpermissioninwritingfromthepublisher.Detailsonhowtoseekpermission,furtherinformationaboutthePublisher’spermissionspoliciesandourarrangementswithorganizationssuchastheCopyrightClearanceCenterandtheCopyrightLicensingAgency,canbefoundatourwebsite:www.elsevier.com/permissions.ThisbookandtheindividualcontributionscontainedinitareprotectedundercopyrightbythePublisher(otherthanasmaybenotedherein).NoticesKnowledgeandbestpracticeinthisfieldareconstantlychanging.Asnewresearchandexperiencebroadenourunderstanding,changesinresearchmethods,professionalpractices,ormedicaltreatmentmaybecomenecessary.Practitionersandresearchersmustalwaysrelyontheirownexperienceandknowledgeinevaluatingandusinganyinformation,methods,compounds,orexperimentsdescribedherein.Inusingsuchinformationormethodstheyshouldbemindfuloftheirownsafetyandthesafetyofothers,includingpartiesforwhomtheyhaveaprofessionalresponsibility.Tothefullestextentofthelaw,neitherthePublishernortheauthors,contributors,oreditors,assumeanyliabilityforanyinjuryand/ordamagetopersonsorpropertyasamatterofproductsliability,negligenceoro...
