ClinicalTrialsinOsteoporosisSecondEditionClinicalTrialsinOsteoporosisSecondEditionEditedbyDerekPearsonandColinG.MillerBritishLibraryCataloguinginPublicationDataClinicaltrialsinosteoporosis-2nded.1.Osteoporosis-Chemotherapy-Research-Handbooks,manuals,etc.2.Drugs-Testing-Handbooks,manuals,etc.I.Pearson,Derek,1954-II.Miller,ColinG.,1960-616.7�16LibraryofCongressControlNumber:2006931121ISBN-10:1-84628-389-22ndeditione-ISBN-10:1-84628-587-92ndeditionISBN-13:978-1-84628-389-52ndeditione-ISBN-13:978-1-84628-587-52ndeditionISBN-10:1-85233-229-81steditionPrintedonacid-freepaper©Springer-VerlagLondonLimited2007Firstpublished2002Secondedition2007Apartfromanyfairdealingforthepurposesofresearchorprivatestudy,orcriticismorreview,aspermittedundertheCopyright,DesignsandPatentsAct1988,thispublicationmayonlybereproduced,storedortransmitted,inanyformorbyanymeans,withthepriorpermissioninwritingofthepublishers,orinthecaseofreprographicreproductioninaccordancewiththetermsoflicencesissuedbytheCopyrightLicensingAgency.Enquiriesconcerningreproductionoutsidethosetermsshouldbesenttothepublishers.Theuseofregisterednames,trademarks,etc.inthispublicationdoesnotimply,evenintheabsenceofaspecificstatement,thatsuchnamesareexemptfromtherelevantlawsandregulationsandthereforefreeforgeneraluse.Productliability:Thepublishercangivenoguaranteeforinformationaboutdrugdosageandapplicationthereofcontainedinthisbook.Ineveryindividualcasetherespectiveusermustcheckitsaccuracybyconsultingotherpharmaceuticalliterature.987654321SpringerScience+BusinessMediaspringer.comDerekPearson,BSc,PhDJointServiceManagerMedicalPhysics&ClinicalEngineeringDepartmentNottinghamUniversityHospitalsNHSTrustNottinghamUKColinG.Miller,PhD,FICRSr.VicePresidentMedicalAffairsBio-ImagingTechnologiesInc.Newtown,PAUSAvForewordtotheFirstEditionBeforethemid-1990s,veryfewpeoplewereawareofthediseaseofosteoporosis,notonlyinthegeneralpopulation,butalsointhemedicalprofession.Inthepast10yearstherehavebeenmanyadvancesanddevelopmentsintheunderstandin...