ClinicaltrialsinpsychiatryBrianS.EverittProfessorofBehaviouralStatistics,InstituteofPsychiatry,King’sCollege,London,UKandSimonWesselyDepartmentofPsychologicalmedicine,GKTSchoolofMedicineandInstituteofPsychiatry,London,UKThispageintentionallyleftblankClinicaltrialsinpsychiatryGreatClarendonStreet,OxfordOX26DPOxfordUniversityPressisadepartmentoftheUniversityofOxford.ItfurtherstheUniversity’sobjectiveofexcellenceinresearch,scholarship,andeducationbypublishingworldwideinOxfordNewYorkAucklandBangkokBuenosAiresCapeTownChennaiDaresSalaamDelhiHongKongIstanbulKarachiKolkataKualaLumpurMadridMelbourneMexicoCityMumbaiNairobiSaoPauloShanghaiTaipeiTokyoTorontoOxfordisaregisteredtrademarkofOxfordUniversityPressintheUKandincertainothercountriesPublishedintheUnitedStatesbyOxfordUniversityPressInc.,NewYork©OxfordUniversityPress,2004ThemoralrightsoftheauthorhavebeenassertedDatabaserightOxfordUniversityPress(maker)Firstpublished2004Allrightsreserved.Nopartofthispublicationmaybereproduced,storedinaretrievalsystem,ortransmitted,inanyformorbyanymeans,withoutthepriorpermissioninwritingofOxfordUniversityPress,orasexpresslypermittedbylaw,orundertermsagreedwiththeappropriatereprographicsrightsorganization.EnquiriesconcerningreproductionoutsidethescopeoftheaboveshouldbesenttotheRightsDepartment,OxfordUniversityPress,attheaddressaboveYoumustnotcirculatethisbookinanyotherbindingorcoverandyoumustimposethissameconditiononanyacquirerBritishLibraryCataloguinginPublicationDataDataavailableISBN019852642310987654321TypesetbyIntegraSoftwareServicesPvt.Ltd,Pondicherry,IndiaPrintedinGreatBritainonacid-freepaperbyBiddlesLtd.,Guildford&King’sLynn.PrefaceEstimatesoftheannualcostofmentalhealthproblemstotheUnitedKingdomrangefrom£7bnto£32bn;mentalhealthaccountsforaquarterofallGPconsul-tations.Giventhesefiguresitisnotsurprisingthatthesearchforeffectivetreat-mentsinpsychiatrycontinuesapace.Fromnewdrugtherapiesforschizophreniatotheuseofcognitivebehaviourtherapyinmanagingdepression,psychiatricresearchworke...
