CardiovascularClinicalTrialsCardiovascularClinicalTrialsPUTTINGTHEEVIDENCEINTOPRACTICEEditedbyMarcusD.Flather,MBBS,FRCPProfessorofMedicineandClinicalTrialsUniversityofEastAngliaandNorfolkandNorwichUniversityHospitalNorwich,UKDeepakL.Bhatt,MD,MPH,FACC,FAHA,FESCChiefofCardiology,VABostonHealthcareSystem;Director,IntegratedInterventionalCardiovascularProgram,BrighamandWomen’sHospital&VABostonHealthcareSystem;ProfessorofMedicine,HarvardMedicalSchool;SeniorInvestigator,TIMIStudyGroupBoston,MA,USATobiasGeisler,MDAssociateProfessorofMedicineConsultant,CardiologyUniversityHospitalTübingenTübingenMedicalSchoolTübingen,GermanyAJohnWiley&Sons,Ltd.,PublicationThiseditionfirstpublished2013,©2013byBlackwellPublishing.BMJBooksisanimprintofBMJPublishingGroupLimited,usedunderlicencebyBlackwellPublishingwhichwasacquiredbyJohnWiley&SonsinFebruary2007.Blackwell’spublishingprogrammehasbeenmergedwithWiley’sglobalScientific,TechnicalandMedicalbusinesstoformWiley-Blackwell.Registeredoffice:JohnWiley&Sons,Ltd,TheAtrium,SouthernGate,Chichester,WestSussex,PO198SQ,UKEditorialoffices:9600GarsingtonRoad,Oxford,OX42DQ,UKTheAtrium,SouthernGate,Chichester,WestSussex,PO198SQ,UK111RiverStreet,Hoboken,NJ07030-5774,USAFordetailsofourglobaleditorialoffices,forcustomerservicesandforinformationabouthowtoapplyforpermissiontoreusethecopyrightmaterialinthisbookpleaseseeourwebsiteatwww.wiley.com/wiley-blackwellTherightoftheauthortobeidentifiedastheauthorofthisworkhasbeenassertedinaccordancewiththeUKCopyright,DesignsandPatentsAct1988.Allrightsreserved.Nopartofthispublicationmaybereproduced,storedinaretrievalsystem,ortransmitted,inanyformorbyanymeans,electronic,mechanical,photocopying,recordingorotherwise,exceptaspermittedbytheUKCopyright,DesignsandPatentsAct1988,withoutthepriorpermissionofthepublisher.Designationsusedbycompaniestodistinguishtheirproductsareoftenclaimedastrademarks.Allbrandnamesandproductnamesusedinthisbookaretradenames,servicemarks,trademarksorregisteredtrademarksoftheirrespectiveown...
