StatiSticSinPracticeSarahr.BrownwalterM.GreGorychriStwelveSJuliaBrownAPracticalGuidetoDesigningPhaseIITrialsinOncologyAPracticalGuidetoDesigningPhaseIITrialsinOncologySTATISTICSINPRACTICESeriesAdvisorsHumanandBiologicalSciencesStephenSennCRP-Sant´e,LuxembourgEarthandEnvironmentalSciencesMarianScottUniversityofGlasgow,UKIndustry,CommerceandFinanceWolfgangJankUniversityofMaryland,USAFoundingEditorVicBarnettNottinghamTrentUniversity,UKStatisticsinPracticeisanimportantinternationalseriesoftextswhichprovidedetailedcoverageofstatisticalconcepts,methodsandworkedcasestudiesinspecificfieldsofinvestigationandstudy.Withsoundmotivationandmanyworkedpracticalexamples,thebooksshowindown-to-earthtermshowtoselectanduseanappropriaterangeofstatisticaltechniquesinaparticularpracticalfieldwithineachtitle’sspecialtopicarea.Thebooksprovidestatisticalsupportforprofessionalsandresearchworkersacrossarangeofemploymentfieldsandresearchenvironments.Subjectareascov-eredincludemedicineandpharmaceutics;industry,financeandcommerce;publicservices;theearthandenvironmentalsciences;andsoon.Thebooksalsoprovidesupporttostudentsstudyingstatisticalcoursesappliedtotheaboveareas.Thedemandforgraduatestobeequippedfortheworkenvironmenthasledtosuchcoursesbecomingincreasinglyprevalentatuniversitiesandcolleges.Itisouraimtopresentjudiciouslychosenandwell-writtenworkbookstomeeteverydaypracticalneeds.Feedbackofviewsfromreaderswillbemostvaluabletomonitorthesuccessofthisaim.Acompletelistoftitlesinthisseriesappearsattheendofthevolume.APracticalGuidetoDesigningPhaseIITrialsinOncologySarahR.BrownUniversityofLeeds,UKWalterM.GregoryUniversityofLeeds,UKChrisTwelvesStJames’sUniversityHospital,Leeds,UKJuliaBrownUniversityofLeeds,UKThiseditionfirstpublished2014©2014JohnWiley&Sons,LtdRegisteredofficeJohnWiley&SonsLtd,TheAtrium,SouthernGate,Chichester,WestSussex,PO198SQ,UnitedKingdomFordetailsofourglobaleditorialoffices,forcustomerservicesandforinformationabouthowtoapplyforpermissiontoreusethecopyrightmaterialinthisbookple...