ClinicalTrialsinNeurologyDesign,Conduct,AnalysisClinicalTrialsinNeurologyDesign,Conduct,AnalysisBernardRavina,MD,MSMedicalDirector,TranslationalNeurology,BiogenIdec,Cambridge,MA,USAJeffreyCummings,MDDirector,ClevelandClinicLouRuvoCenterforBrainHealthinNevada,Ohio,andFlorida,USAMichaelP.McDermott,PhDProfessorofBiostatistics,andProfessorofNeurology,UniversityofRochesterSchoolofMedicine,Rochester,NY,USAR.MichaelPoole,MD,FACPHead,CNSandPainInnovativeMedicineUnit,AstraZenecaPLC,Waltham,MA,USAEditedbycambridgeuniversitypressCambridge,NewYork,Melbourne,Madrid,CapeTown,Singapore,SãoPaulo,Delhi,MexicoCityCambridgeUniversityPressheEdinburghBuilding,CambridgeCB28RU,UKPublishedintheUnitedStatesofAmericabyCambridgeUniversityPress,NewYorkwww.cambridge.orgInformationonthistitle:www.cambridge.org/9780521762595©CambridgeUniversityPress2012hispublicationisincopyright.Subjecttostatutoryexceptionandtotheprovisionsofrelevantcollectivelicensingagreements,noreproductionofanypartmaytakeplacewithoutthewrittenpermissionofCambridgeUniversityPress.Firstpublished2012PrintedintheUnitedKingdomattheUniversityPress,CambridgeAcataloguerecordforthispublicationisavailablefromtheBritishLibraryLibraryofCongressCataloguinginPublicationdataClinicaltrialsinneurology:design,conduct,analysis/editedbyBernardRavina...[etal.].p.cm.Includesbibliographicalreferencesandindex.ISBN978-0-521-76259-5(hardback)1.Neurology–Research–Methodology.2.Clinicaltrials.I.Ravina,Bernard.RC337.C622012616.80072′4–dc232012000303ISBN978-0-521-76259-5HardbackCambridgeUniversityPresshasnoresponsibilityforthepersistenceoraccuracyofURLsforexternalorthird-partyinternetwebsitesreferredtointhispublication,anddoesnotguaranteethatanycontentonsuchwebsitesis,orwillremain,accurateorappropriate.Everyeforthasbeenmadeinpreparingthisbooktoprovideaccurateandup-to-dateinformationwhichisinaccordwithacceptedstandardsandpracticeatthetimeofpublication.Althoughcasehistoriesaredrawnfromactualcases,everyeforthasbeenmadetodisguisetheidentitiesofthein...
