第53卷第11期2023年11月Vol.53No.11Nov.2023·1315·日用化学工业（中英文）ChinaSurfactantDetergent&CosmeticsReceived:October27,2022.;Revised:October26,2023.*Correspondingauthor.Tel.:+86-13817107438,E-mail:429686213@qq.com.DOI：10.3969/j.issn.2097-2806.2023.11.011Metalions:thebiologicaleffectsonskinandtheapplicationincosmeticsXiaoyuMa*,XiaojuanYan,XijunBao（FosunCosmetics（ShangHai）Bio-TechnologyCo.,Ltd.,Shanghai200233,China）Abstract:Skintissuesarerichinmetalions.Duetothecomplexityofskinstructure,theseionsexistinbothfreeandboundforms.Metalionshavebeeninvolvedinmanybiologicalprocesses,suchasmaintainingbarrierhomeostasis,stimulatingwoundhealing,andbalancingredoxstate.Giventheiruniquecharacteristicsofmulti-targetsandmulti-pathways,metalionsarewidelyusedinskincareapplications,exhibitingthefunctionsofpromotingskinrepairing,soothing,wrinklereduction,tightening,whitening,etc.Herein,thebiologicaleffectsandcosmeticapplicationsofmetalions,includingcalcium,magnesium,potassium,zinc,strontiumandcopper,weresystematicallyreviewed.Theconcentrationanddistributionofcommonmetalionsinskinweresummarized.Thedermatologiceffectsandmechanismswerealsoconcluded.Calcium,magnesiumandpotassiumionswererelativelyabundantinskin,andtheycouldplayimportantrolesinstimulatingwoundhealing,maintainingintegrityofskinbarrier,andstrengtheningthebarrier.Forthoseionswithtraceamount,suchaszinc,strontium,copper,ironandmanganese,theycouldexertspecificskinfunctionsincludinginflammationinhibition,reductionofskinsensitivity,ormodulationofredoxsystem.Inaddition,themetalion-relatedactiveingredientsincosmeticrawmaterialsweresummarizedandtheirskinfunctionswerereviewed.Finally,thecurrentlimitsandchallengesfortheuseofmetalionsinskincareproductswereproposed.Thisreviewcouldshednewlightonthedesignoffunctionalformulasandnovelactivecomponents.Keywords:metalion;barrierrepair;skinhomeostasis;woundhealing;inflammationDSBSG+SSSCNa+K+Mg2+Ca2+Fe2+Cu2+Zn2+·1316·第53卷专论与综述日用化学工业（中英文）自古以来，人们就发现天然来源的海...
