2023年2月第30卷第2期丁螺环酮联合舍曲林治疗对伴有焦虑症状的抑郁症患者情绪变化及认知功能的影响贾四杰，贾萌，陈清莲（周口市扶沟县精神病医院精神病科，河南周口461300）【摘要】目的探讨丁螺环酮联合舍曲林治疗对伴有焦虑症状的抑郁症患者情绪变化及认知功能的影响。方法80例伴有焦虑症状的抑郁症患者随机分为两组，对照组采用舍曲林治疗，观察组采用丁螺环酮联合舍曲林治疗，比较两组的情绪、认知功能及不良反应。结果治疗后，两组的HAMD、HAMA评分均较治疗前降低，MoCA评分均较治疗前升高（P＜0．05）；且与对照组相比，观察组的HAMD、HAMA评分均更低，MoCA评分更高（P＜0．05）。两组的不良反应发生率比较，差异无统计学意义（P＞0．05）。结论丁螺环酮联合舍曲林治疗可有效改善伴有焦虑症状抑郁症患者的负性情绪，提高患者的认知功能，且安全性较高。【关键词】抑郁症；焦虑症状；丁螺环酮；舍曲林；情绪；认知功能中图分类号：R749.4文献标识码：Adoi:10.3969/j.issn.1674-4659.2023.02.0213ImpactofBuspironeCombinedwithSertralineTreatmentonEmotionalChangesandCognitiveFunctionofDepressionPa-tientswithAnxietySymptoms//JIASijie,JIAMeng,CHENQinglian(DepartmentofPsychiatry,FugouCountyPsychiatricHospital,Zhoukou461300,China)[Abstract]ObjectiveToexploretheimpactofbuspironecombinedwithsertralinetreatmentonemotionalchangesandcognitivefunctionofdepressionpatientswithanxietysymptoms.Methods80casesofdepressionpatientswithanxietysymptomswererandomlydividedintotwogroups.Thecontrolgroupwastreatedwithsertraline,andtheobservationgroupwastreatedwithbuspironecombinedwithsertraline.Theemotions,cognitivefunctionandadversereactionswerecomparedbetweenthetwogroups.ResultsAftertreatment,theHAMDandHAMAscoresofthetwogroupswerelowerthanthosebeforetreatment,andtheMoCAscoreswerehigherthanthosebeforetreatment(P<0.05);Comparedwiththecontrolgroup,theHAMDandHAMAscoresoftheobservationgroupwerelower,andtheMoCAscorewashigher(P<0.05).Nosignificantdifferencewasfoundintheincidenceofadversereactionsbetweenthetwogroups(P>0.05).ConclusionsBuspironecombinedwithsertralinetreatmentcaneffectivelyimprovethenegativeemotionsandimprovethecognitivefunctionofdepressionpatientswit...
