东南大学学报(医学版)JSoutheastUniv(MedSciEdi)2022,Dec;41(6):773⁃777现出区别于空载及单靶向微泡的黏附力和解离能力,能在较高剪切力下实现与靶分子的有效结合,有望在活体状态下实现大动脉的超声分子影像学成像并实时动态评估EG功能紊乱状态。[参考文献][1]CAPUANAF,PHINIKARIDOUA,STEFANIAR,etal.Ima⁃gingofdysfunctionalelastogenesisinatherosclerosisusinganimprovedgadolinium⁃basedtetramericMRIprobetargetedtotropoelastin[J].JMedChem,2021,64(20):15250⁃15261.[2]LISS,IPCKM,TANGMYH,etal.Sialyllewisx⁃P⁃selectincascademediatestumor⁃mesothelialadhesioninasciticfluidshearflow[J].NatCommun,2019,10(1):2406.[3]DUIVENVOORDENR,MULDERWJM.Imagingtropoelastininatherosclerosis[J].CircCardiovascImaging,2018,11(8):e008147.[4]BJORKEGRENJLM,LUSISAJ.Atherosclerosis:recentde⁃velopments[J].Cell,2022,185(10):1630⁃1645.[5]BARALLOBRE⁃BARREIROJ,LOEYSB,MAYRM,etal.Ex⁃tracellularmatrixinvasculardisease,part2/4:JACCfocusseminar[J].JAmCollCardiol,2020,75(17):2189⁃2203.[6]MOCANUCA,FUIOREV,VOICUG,etal.P⁃selectintarge⁃tedRAGE⁃shRNAlipoplexesalleviateatherosclerosis⁃associat⁃edinflammation[J].JControlRelease,2021,338:754⁃772.[7]OZ...