lncRNA调控蛋白磷酸化抑制pathway：A Cytoplasmic NF-kB Interacting Long Noncoding RNA Blocks IkB Phosphorylation and Suppresses Breast Cancer Metastasis.pdfVIP免费

ArticleACytoplasmicNF-kBInteractingLongNoncodingRNABlocksIkBPhosphorylationandSuppressesBreastCancerMetastasisGraphicalAbstractHighlightsdNF-kBinteractinglongnoncodingRNA(NKILA)directlyblocksIkBphosphorylationdNKILAinteractswithNF-kB/IkBtoformastableternarycomplexdNKILAisanegativefeedbackregulatorofNF-kBinbothrestingandactivatedcellsdDecreasedNKILAininvasivebreastcancerisassociatedwithpoorpatientoutcomeAuthorsBoduLiu,LijuanSun,...,MushengZeng,ErweiSongCorrespondencesongew@mail.sysu.edu.cnInBriefLiuetal.identifyanNF-KappaBInteractingLncRNA(NKILA)thatbindstoNF-kB/IkBcomplexandrepressesNF-kBsignalingandcancer-associatedinflammation.LowNKILAexpressionisassociatedwithbreastcancermetastasisandpoorpatientprognosis.AccessionNumbersGSE57539Liuetal.,2015,CancerCell27,370–381March9,2015ª2015ElsevierInc.http://dx.doi.org/10.1016/j.ccell.2015.02.004CancerCellArticleACytoplasmicNF-kBInteractingLongNoncodingRNABlocksIkBPhosphorylationandSuppressesBreastCancerMetastasisBoduLiu,1,2,3,7LijuanSun,1,2,3,7QiangLiu,1,2,7ChangGong,1,2,7YandanYao,1,2XiaobinLv,1,2LingLin,4HeruiYao,1,2FengxiSu,1,2DangshengLi,5MushengZeng,6andErweiSong1,2,3,*1BreastTumorCenter,SunYat-senMemorialHospital,SunYat-senUniversity,Guangzhou510120,China2KeyLaboratoryofMalignantTumorGeneRegulationandTargetTherapyofGuangdongHigherEducationInstitutes,SunYat-senMemorialHospital,SunYat-senUniversity,Guangzhou510120,China3KeyLaboratoryofGeneEngineeringofMinistryofEducation,StateKeyLaboratoryofBiocontrol,SchoolofLifeSciences,SunYat-senUniversity,Guangzhou510275,China4DepartmentofInternalMedicine,TheFirstAffiliatedHospital,ShantouUniversityMedicalCollege,Shantou515041,China5ShanghaiInstitutesforBiologicalSciences,ChineseAcademyofSciences,320YueyangRoad,Shanghai200031,China6StateKeyLaboratoryofOncologyinSouthernChina,CancerCenter,SunYat-senUniversity,Guangzhou510060,China7Co-firstauthor*Correspondence:songew@mail.sysu.edu.cnhttp://dx.doi.org/10.1016/j.ccell.2015.02.004SUMMARYNF-kBisacriticallinkbetweeninflammationandcanc...