ArticleN6-methyladenineDNAModificationinGlioblastomaGraphicalAbstractHighlightsdN6-methyladenineDNAmodificationismarkedlyupregulatedinglioblastomadN6-mAco-localizeswithH3K9me3-markedheterochromatindomainsdTheDNAdemethylaseALKBH1dynamicallycontrolsN6-mAlevelsdTargetingN6-mAregulationkillsglioblastomastemcellsAuthorsQiXie,TaoP.Wu,RyanC.Gimple,...,AndrewE.Sloan,AndrewZ.Xiao,JeremyN.RichCorrespondenceandrew.xiao@yale.edu(A.Z.X.),drjeremyrich@gmail.com(J.N.R.)InBriefN6-methyladenineDNAmodificationsareenrichedinhumanglioblastoma,andtargetingregulatorsofthismodificationcaninhibitcancergrowthbyalteringheterochromatinlandscapesanddownregulatingoncogenicprograms.GlioblastomaSurvivalandProgressionNormalCellGlioblastomaCellDNAN6-mAALKBH1DemethylaseHypoxiaResponseGenesOncogenicGenesH3K9me3H3K9me3H3C3H3CN6-mAN6-mAH3K9me3H3CN6-mANervousSystemDevelopmentGenesALKBH1Xieetal.,2018,Cell175,1228–1243November15,2018ª2018ElsevierInc.https://doi.org/10.1016/j.cell.2018.10.006ArticleN6-methyladenineDNAModificationinGlioblastomaQiXie,1,15TaoP.Wu,2,14,15RyanC.Gimple,1,3,15ZhengLi,2BrianaC.Prager,1,3,4QiulianWu,1YangYu,5PengchengWang,5YinshengWang,5DavidU.Gorkin,6ChengZhang,6AlexisV.Dowiak,6KaixuanLin,2ChunZeng,7YinghuiSui,7LeoJ.Y.Kim,1,3TylerE.Miller,3LiJiang,1ChristineH.Lee,8ZhiHuang,9XiaoguangFang,9KuiZhai,9StephenC.Mack,10MaikeSander,7ShidengBao,9AmberE.Kerstetter-Fogle,11,12AndrewE.Sloan,11,12AndrewZ.Xiao,2,*andJeremyN.Rich1,13,16,*1DepartmentofMedicine,DivisionofRegenerativeMedicine,UniversityofCalifornia,SanDiego,LaJolla,CA92037,USA2DepartmentofGeneticsandYaleStemCellCenter,YaleSchoolofMedicine,NewHaven,CT06520,USA3DepartmentofPathology,CaseWesternReserveUniversity,Cleveland,OH44120,USA4ClevelandClinicLernerCollegeofMedicine,CaseWesternReserveUniversity,Cleveland,OH44195,USA5DepartmentofChemistry,UniversityofCalifornia,Riverside,Riverside,CA92521,USA6CenterforEpigenomics,DepartmentofCellularandMolecularMedicine,UniversityofCalifornia,SanDiego,LaJolla,CA92037,USA7DepartmentsofPediat...
