ArticleCircadianClockRegulationofHepaticLipidMetabolismbyModulationofm6AmRNAMethylationGraphicalAbstractHighlightsdKnockoutofBmal1intheliverdisruptslipidmetabolismdDeletionofBmal1increasesm6Alevels,particularlyinPPaRamRNAdMETTL3andYTHDF2uniquelyimpactPPaRamRNAdecayandtranscriptdDisruptedBmal1drivesROS-inducedincreasesofm6AlevelsinPPaRatranscriptAuthorsXiangZhong,JiayaoYu,KatyaFrazier,...,ChuanHe,EugeneB.Chang,VanessaLeoneCorrespondencezhongxiang@njau.edu.cn(X.Z.),echang@medicine.bsd.uchicago.edu(E.B.C.),vleone@bsd.uchicago.edu(V.L.)InBriefZhongetal.revealthathepaticBmal1deletionchangesm6AmRNAmethylation,particularlyofPPaRa.METTL3orYTHDF2knockdownaffectsPPaRatranscriptionandtranslation,impactingdownstreamlipidmetabolism.Thesefindingsfurtherrevealtheoverlapbetweencircadiangenenetworkdisruption,mRNAm6Amodifications,andmetabolicstate.Zhongetal.,2018,CellReports25,1816–1828November13,2018ª2018TheAuthors.https://doi.org/10.1016/j.celrep.2018.10.068CellReportsArticleCircadianClockRegulationofHepaticLipidMetabolismbyModulationofm6AmRNAMethylationXiangZhong,1,2,9,*JiayaoYu,1KatyaFrazier,2XiaochengWeng,3,4,5,6YiLi,1CandaceM.Cham,2KyleDolan,2XiaorongZhu,2NathanielHubert,2YunTao,2FanfeiLin,2KristinaMartinez-Guryn,2,7YongHuang,2TianWang,1JianzhaoLiu,3,4,5,8ChuanHe,3,4,5EugeneB.Chang,2,9,10,*andVanessaLeone2,9,*1CollegeofAnimalScienceandTechnology,NanjingAgriculturalUniversity,Jiangsu,Nanjing210095,PRChina2DepartmentofMedicine,UniversityofChicago,Chicago,IL60637,USA3DepartmentofChemistry,UniversityofChicago,Chicago,IL60637,USA4DepartmentofBiochemistryandMolecularBiology,UniversityofChicago,Chicago,IL60637,USA5HowardHughesMedicalInstitute,UniversityofChicago,Chicago,IL60637,USA6Presentaddress:CollegeofChemistryandMolecularSciences,WuhanUniversity,Hubei,Wuhan430072,China7Presentaddress:BiomedicalSciencesProgram,MidwesternUniversity,DownersGrove,IL60515,USA8Presentaddress:DepartmentofPolymerScienceandEngineering,ZhejiangUniversity,Zhejiang,Hangzhou310027,China9Theseauthorscontr...
