神经胶质瘤：m6A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program.pdfVIP免费

Articlem6ADemethylaseALKBH5MaintainsTumorigenicityofGlioblastomaStem-likeCellsbySustainingFOXM1ExpressionandCellProliferationProgramGraphicalAbstractHighlightsdALKBH5expressionincreasesinGSCsandpredictspoorsurvivalinGBMpatientsdALKBH5demethylatesFOXM1nascenttranscriptsandenhancesFOXM1expressiondFOXM1-ASpromotestheinteractionofFOXM1nascenttranscriptswithALKBH5dALKBH5-FOXM1pathwayiscriticalforGSCproliferationandtumorigenesisAuthorsSicongZhang,BoxuanSimenZhao,AidongZhou,...,SadhanMajumder,ChuanHe,SuyunHuangCorrespondencesuhuang@mdanderson.orgInBriefZhangetal.revealthatelevatedRNAm6AdemethylaseALKBH5inglioblastomastem-likecellsenhancesself-renewalandtumorigenesisthroughregulationofFOXM1.ThelncRNAantisensetoFOXM1promotestheinteractionofALKBH5withFOXM1nascentRNA,leadingtodemethylationandelevatedexpressionofFOXM1.Zhangetal.,2017,CancerCell31,591–606April10,2017ª2017ElsevierInc.http://dx.doi.org/10.1016/j.ccell.2017.02.013CancerCellArticlem6ADemethylaseALKBH5MaintainsTumorigenicityofGlioblastomaStem-likeCellsbySustainingFOXM1ExpressionandCellProliferationProgramSicongZhang,1,2BoxuanSimenZhao,3,4AidongZhou,1KangyuLin,1ShaopingZheng,1ZhikeLu,3,4YaohuiChen,1ErikP.Sulman,5KepingXie,2,6OliverBo¨gler,1,2SadhanMajumder,7ChuanHe,3,4,8andSuyunHuang1,2,9,*1DepartmentofNeurosurgery,TheUniversityofTexasMDAndersonCancerCenter,Houston,TX77030,USA2PrograminCancerBiology,TheUniversityofTexasMDAndersonCancerCenterUTHealthGraduateSchoolofBiomedicalSciences,Houston,TX77030,USA3DepartmentofChemistryandInstituteforBiophysicalDynamics4HowardHughesMedicalInstituteTheUniversityofChicago,Chicago,IL60637,USA5DepartmentofRadiationOncology6DepartmentofGastroenterology,Hepatology&Nutrition7DepartmentofGeneticsTheUniversityofTexasMDAndersonCancerCenter,Houston,TX77030,USA8DepartmentofBiochemistryandMolecularBiology,TheUniversityofChicago,Chicago,IL60637,USA9LeadContact*Correspondence:suhuang@mdanderson.orghttp://dx.doi.org/10.1016/j.ccell.2017.02.013SUMMARYThedynamicandreversibleN6-methyladenosine...