m6AmRNAmethylationcontrolsTcellhomeostasisbytargetingIL-7/STAT5/SOCSpathwayHua-BingLi1,*,§,JiyuTong1,2,*,ShuZhu1,*,PedroJ.Batista3,ErinE.Duffy4,5,JunZhao1,6,WillBailis1,GuangchaoCao1,2,LinaKroehling1,YuanyuanChen1,7,GengWang1,JamesP.Broughton3,Y.GraceChen3,YuvalKluger6,MatthewD.Simon4,5,HowardY.Chang3,ZhinanYin2,§,andRichardA.Flavell1,8,§1DepartmentofImmunobiology,YaleUniversitySchoolofMedicine,NewHaven,CT065202TheFirstAffiliatedHospital,BiomedicalTranslationalResearchInstituteandGuangdongProvinceKeyLaboratoryofMolecularImmunologyandAntibodyEngineering,JinanUniversity,Guangzhou510632,P.R.China3DynamicRegulomes,StanfordUniversity,Stanford,CA94305,USA4DepartmentofMolecularBiophysics&Biochemistry,YaleUniversity,NewHaven,CT06511,USA5ChemicalBiologyInstitute,YaleUniversity,WestHaven,CT06516,USA6DepartmentofPathology,YaleUniversitySchoolofMedicine,NewHaven,CT065207InstituteofSurgicalResearch,DapingHospital,theThirdMilitaryMedicalUniversity,Chongqing,China4000388HowardHughesMedicalInstitute,ChevyChase,MD20815-6789,USAAbstractN6-methyladenosine(m6A)isthemostcommonandabundantmessengerRNAmodification,modulatedby‘writers’,‘erasers’and‘readers’ofthismark1,2.Invitrodatahaveshownthatm6AUsersmayview,print,copy,anddownloadtextanddata-minethecontentinsuchdocuments,forthepurposesofacademicresearch,subjectalwaystothefullConditionsofuse:http://www.nature.com/authors/editorial_policies/license.html#termsReprintsandpermissionsinformationisavailableatwww.nature.com/reprints§CorrespondingAuthors:RichardA.Flavell,Ph.D.,FRS,DepartmentofImmunobiology,YaleUniversitySchoolofMedicine,300CedarStreet,TACS-569,NewHaven,CT06520,(203)737-2216(phone),(203)737-2958(FAX),richard.flavell@yale.edu.Hua-BingLi,Ph.D.,DepartmentofImmunobiology,YaleUniversitySchoolofMedicine,300CedarStreet,TACS-569,NewHaven,CT06520,huabing.li@yale.edu.ZhinanYin,Ph.D.,TheFirstAffiliatedHospital,BiomedicalTranslationalResearchInstituteandGuangdongProvinceKeyLaboratoryofMolecularImmunologyandAntibodyEngineering,Jinan...
