ArticleCirc-ZNF609IsaCircularRNAthatCanBeTranslatedandFunctionsinMyogenesisGraphicalAbstractHighlightsdCircRNAsareconserved,abundant,andregulatedinmyogenesisdHigh-throughputphenotypicscreeningrevealsfunctionalcircRNAsdCirc-ZNF609regulatesmyoblastproliferationdCirc-ZNF609canbetranslatedAuthorsIvanoLegnini,GaiaDiTimoteo,FrancescaRossi,...,PietroLaneve,NikolausRajewsky,IreneBozzoniCorrespondenceirene.bozzoni@uniroma1.itInBriefLegninietal.identifiedcirc-ZNF609,acircularRNAexpressedinmurineandhumanmyoblasts,whichcontrolsmyoblastproliferation.Circ-ZNF609containsanopenreadingframeandistranslatedintoaproteininasplicing-dependent/cap-independentmanner.Circ-ZNF609translationcanbemodulatedbystressconditions.Legninietal.,2017,MolecularCell66,1–16April6,2017ª2017TheAuthors.PublishedbyElsevierInc.http://dx.doi.org/10.1016/j.molcel.2017.02.017MolecularCellArticleCirc-ZNF609IsaCircularRNAthatCanBeTranslatedandFunctionsinMyogenesisIvanoLegnini,1GaiaDiTimoteo,1FrancescaRossi,1MariangelaMorlando,1FrancescaBriganti,1OlgaSthandier,1AlessandroFatica,1TizianaSantini,2AdrianAndronache,3MarkWade,3PietroLaneve,2NikolausRajewsky,4andIreneBozzoni1,2,5,6,*1DepartmentofBiologyandBiotechnologyCharlesDarwinandIBPM,SapienzaUniversityofRome,P.leA.Moro5,00185Rome,Italy2CenterforLifeNanoScience@Sapienza,IstitutoItalianodiTecnologia,VialeReginaElena291,00161Rome,Italy3CenterforGenomicScienceofIIT@SEMM,FondazioneIstitutoItalianodiTecnologia(IIT),ViaAdamello16,20139Milan,Italy4BerlinInstituteforMedicalSystemsBiology,Max-Delbr€uckCenterforMolecularMedicine,Robert-Ro¨ssle-Strasse10,13125Berlin,Germany5InstitutPasteurItaly,FondazioneCenci-Bolognetti,SapienzaUniversityofRome,P.leA.Moro5,00185Rome,Italy6LeadContact*Correspondence:irene.bozzoni@uniroma1.ithttp://dx.doi.org/10.1016/j.molcel.2017.02.017SUMMARYCircularRNAs(circRNAs)constituteafamilyoftran-scriptswithuniquestructuresandstilllargelyun-knownfunctions.Theirbiogenesis,whichproceedsviaaback-splicingreaction,isfairlywellcharacter-ized,whereasthei...
