HepatitisBvirus-upregulatedlnc-HUR1promotescellproliferationandtumorigenesisbyblockingp53activityNingningLiu1#,QiLiu1,2#,XiaohaiYang3#,FangZhang1,2,XindaLi1,2,YuanwuMa4,FeifeiGuan4,XinZhao5,ZhiweiLi5,LianfengZhang4,XinYe1,2,6*AuthorsAffiliations:1KeyLaboratoryofPathogenicMicrobiologyandImmunology,InstituteofMicrobiology,ChineseAcademyofSciences(CAS),Beijing100101,China;2UniversityofChineseAcademyofSciences,Beijing100049,China;3InstituteofHealthSciences,AnhuiUniversity,Hefei230031,China;4KeyLaboratoryofHumanDiseaseComparativeMedicine,NHFPC,InstituteofLaboratoryAnimalScience,PekingUnionMedicineCollege,ChineseAcademyofMedicalSciences;5302HospitalofPLA,Beijing100039,China;6SavaidMedicalSchool,UniversityofChineseAcademyofSciences,Beijing100049,China.#NingningLiu,QiLiuandXiaohaiYangcontributeequallytothiswork.*Correspondingauthor:XinYe,KeyLaboratoryofPathogenicMicrobiologyandImmunology,InstituteofMicrobiology,ChineseAcademyofSciences(CAS),Beijing100101,China.Tel/Fax86-10-64807508.Email:yex@im.ac.cn.Keywords:HBV,lnc-HUR1,p53,cellproliferation,tumorigenesisAbbreviations:HBV,hepatitisBvirus;lncRNA,longnon-codingRNA;PCNA,proliferatingcellnuclearantigen;PHx,partialhepatectomy;DEN,diethylnitrosamine;HCC,hepatocarcinoma.Financialsupport:ThisworkwassupportedbytheMinistryofScienceandTechnologyofChina(2016YFC1200304and2015CB910502)，theNationalNaturalScienceFoundationofChina(31600129,and81772989)andtheStrategicPriorityResearchThisarticlehasbeenacceptedforpublicationandundergonefullpeerreviewbuthasnotbeenthroughthecopyediting,typesetting,paginationandproofreadingprocesswhichmayleadtodifferencesbetweenthisversionandtheVersionofRecord.Pleasecitethisarticleasdoi:10.1002/hep.30098Thisarticleisprotectedbycopyright.Allrightsreserved.2ProgramoftheChineseAcademyofSciences(XDPB0301).XinYeisaprincipalinvestigatoroftheInnovativeResearchGroupoftheNationalNaturalScienceFoundationofChina(81621091)AbstractRecentstudieshaveindicatedthatanumberoflncRNAsaredysregulatedinhepatocellularcarcinoma,whi...
