DOI:10.1161/CIRCRESAHA.118.3132071ANovelAngiotensinIIInducedLongNon-CodingRNAGiverRegulatesOxidativeStress,Inflammation,andProliferationinVascularSmoothMuscleCellsSadhanDas1,ErliZhang1,2,ParijatSenapati1,VishnuAmaram1,MarpadgaA.Reddy1,KennethStapleton1,AmyLeung1,LindaLanting1,MeiWang1,ZhuoChen1,MitsuoKato1,HyungJungOh1,QianyunGuo2,XinyueZhang3,BinZhang3,HaitongZhang3,QinghaoZhao3,WeiWang43,YongjianWu3,RamaNatarajan1,51DepartmentofDiabetesComplicationsandMetabolism,DiabetesandMetabolismResearchInstitute,IrellandManellaGraduateSchoolofBiologicalSciences,BeckmanResearchInstituteofCityofHope,Duarte,CA91010;2DepartmentofCardiology;and3CenterforStructuralHeartDiseases,StateKeyLaboratoryofCardiovascularDisease,FuwaiHospital,NationalCenterforCardiovascularDiseases,ChineseAcademyofMedicalSciencesandPekingUnionMedicalCollege,Beijing100037,China.S.D.andE.Z.contributedequallytothismanuscript.Runningtitle:RoleoflncRNAGiverinVSMCdysfunctionSubjectTerms:ACE/AngiotensionReceptors/ReninAngiotensinSystemBasicScienceResearchCellBiology/StructuralBiologyHypertensionVascularBiologyAddresscorrespondenceto:Dr.RamaNatarajanDiabetesComplicationsandMetabolismBeckmanResearchInstituteoftheCityofHope1500EastDuarteRoadDuarte,CA91010Tel.626-218-2289Fax:626-218-0415RNatarajan@coh.orgDr.SadhanDasDiabetesComplicationsandMetabolismBeckmanResearchInstituteoftheCityofHope1500EastDuarteRoadDuarte,CA91010Tel.626-218-4809Sdas@coh.orgDr.YongjianWuCardiology,FuwaiHospitalNationalCenterforCardiovascularDiseasesChineseAcademyofMedicalSciencesPekingUnionMedicalCollege167BeilishiRoadBeijingChinaTel.+86-137-0138-7189Fuwaihosptial@hotmail.comInAugust2018,theaveragetimefromsubmissiontofirstdecisionforalloriginalresearchpaperssubmittedtoCirculationResearchwas12.62days.Downloadedfromhttp://ahajournals.orgbyonOctober9,2018DOI:10.1161/CIRCRESAHA.118.3132072ABSTRACTRationale:AngiotensinII(AngII)-mediatedvascularsmoothmusclecell(VSMC)dysfunctionplaysamajorroleinhypertension.Longnon-codingRNAs(lncRNAs)haveelicitedmuch...
