ArticleRegulatoryTCellsinSkinFacilitateEpithelialStemCellDifferentiationGraphicalAbstractHighlightsdTregactivationinskincloselycorrelateswiththeHFcycledTregslocalizetoHFSCsandplayamajorroleinHFregenerationdTregsfacilitateHFSCproliferationanddifferentiationtoinitiateHFcyclingdTregexpressionofJagged1isrequiredforefficienthairregenerationAuthorsNiwaAli,BaharZirak,RobertSanchezRodriguez,...,GeorgeCotsarelis,AbulK.Abbas,MichaelD.RosenblumCorrespondencemichael.rosenblum@ucsf.eduInBriefLocalizedregulatoryTcells(Tregs)regulatethehairfolliclecyclebydrivingNotch-dependentstemcellproliferationanddifferentiation.Alietal.,2017,Cell169,1119–1129June1,2017ª2017ElsevierInc.http://dx.doi.org/10.1016/j.cell.2017.05.002ArticleRegulatoryTCellsinSkinFacilitateEpithelialStemCellDifferentiationNiwaAli,1,3BaharZirak,1RobertSanchezRodriguez,1MarielaL.Pauli,1Hong-AnTruong,1KevinLai,1RichardAhn,1KaitlinCorbin,2MargaretM.Lowe,1TiffanyC.Scharschmidt,1KeyonTaravati,1MadeleineR.Tan,1RobertoR.Ricardo-Gonzalez,1AudreyNosbaum,1MartaBertolini,4WilsonLiao,1FrankO.Nestle,3RalfPaus,5GeorgeCotsarelis,6AbulK.Abbas,2andMichaelD.Rosenblum1,7,*1DepartmentofDermatology2DepartmentofPathologyUniversityofCalifornia,SanFrancisco,SanFrancisco,CA94143,USA3CutaneousMedicineUnit,St.John’sInstituteofDermatology,King’sCollegeLondon,LondonWC2R2LS,UK4DepartmentofDermatology,UniversityofMuenster,48149Muenster,Germany5CentreforDermatologicalResearch,UniversityofManchester&NIHRManchesterBiomedicalResearchCentre,ManchesterM139PL,UK6DepartmentofDermatology,PerelmanSchoolofMedicine,UniversityofPennsylvania,Philadelphia,PA19104,USA7LeadContact*Correspondence:michael.rosenblum@ucsf.eduhttp://dx.doi.org/10.1016/j.cell.2017.05.002SUMMARYThemaintenanceoftissuehomeostasisiscriticallydependentonthefunctionoftissue-residentimmunecellsandthedifferentiationcapacityoftissue-resi-dentstemcells(SCs).HowimmunecellsinfluencethefunctionofSCsislargelyunknown.RegulatoryTcells(Tregs)inskinpreferentiallylocalizetohairfol-licles(HFs),whichh...
