ArticleCancerCellsCo-opttheNeuronalRedox-SensingChannelTRPA1toPromoteOxidative-StressToleranceGraphicalAbstractHighlightsdTRPA1isoverexpressedincancerandmediatesanon-canonicalROSdefenseprogramdTRPA1promotesROStoleranceviainductionofCa2+-dependentanti-apoptoticpathwaysdNRF2,anoxidant-defensetranscriptionfactor,directlycontrolsTRPA1expressiondTargetingTRPA1reducesxenografttumorgrowthandenhanceschemosensitivityAuthorsNobuakiTakahashi,Hsing-YuChen,IsaacS.Harris,...,YasuoMori,GordonB.Mills,JoanS.BruggeCorrespondencejoan_brugge@hms.harvard.eduInBriefTakahashietal.showthatTRPA1,aneuronalredox-sensingCa2+-influxchanneloverexpressedinhumancancer,upregulatesCa2+-dependentanti-apoptoticpathwaystopromoteROSresistance.NRF2directlycontrolsTRPA1expressionandTRPA1inhibitionsuppressesxenografttumorgrowthandenhanceschemosensitivity.Takahashietal.,2018,CancerCell33,985–1003June11,2018ª2018ElsevierInc.https://doi.org/10.1016/j.ccell.2018.05.001CancerCellArticleCancerCellsCo-opttheNeuronalRedox-SensingChannelTRPA1toPromoteOxidative-StressToleranceNobuakiTakahashi,1Hsing-YuChen,1IsaacS.Harris,1DanielG.Stover,1,2LauraM.Selfors,1RoderickT.Bronson,3ThomasDeraedt,4KarenCichowski,4AlanaL.Welm,5YasuoMori,6GordonB.Mills,7andJoanS.Brugge1,8,*1DepartmentofCellBiology,LudwigCenteratHarvard,HarvardMedicalSchool,Boston,MA02115,USA2DepartmentofMedicalOncology,Dana-FarberCancerInstitute,Boston,MA02115,USA3RodentHistopathologyCore,HarvardMedicalSchool,Boston,MA02115,USA4DepartmentofMedicine,BrighamandWomen’sHospital,HarvardMedicalSchool,Boston,MA02115,USA5DepartmentofOncologicalSciences,HuntsmanCancerInstitute,UniversityofUtah,SaltLakeCity,UT84112,USA6DepartmentofSyntheticChemistryandBiologicalChemistry,GraduateSchoolofEngineering,KyotoUniversity,Kyoto615-8510,Japan7DepartmentofSystemsBiology,TheUniversityofTexasMDAndersonCancerCenter,Houston,TX77030,USA8LeadContact*Correspondence:joan_brugge@hms.harvard.eduhttps://doi.org/10.1016/j.ccell.2018.05.001SUMMARYCancercellsurvivalisdependentonoxidative...
