CrucialroleforNox2andsleepdeprivationinaircraftnoise-inducedvascularandcerebraloxidativestress,inflammation,andgeneregulationSwenjaKro¨ller-Scho¨n1†,AndreasDaiber1,2†,SebastianSteven1,MatthiasOelze1,KatieFrenis1,SanelaKalinovic1,AxelHeimann3,FrankP.Schmidt1,AntonioPinto4,MiroslavaKvandova5,KsenijaVujacic-Mirski1,KonstantinaFilippou1,MarkusDudek6,MarkusBosmann6,MatthiasKlein7,TobiasBopp7,OmarHahad1,PhilippS.Wild2,4,6,KatrinFrauenknecht8,AxelMethner9,ErwinR.Schmidt10,SteffenRapp4,10,HankeMollnau11†,andThomasMu¨nzel1,2*†1CenterforCardiology,CardiologyI-LaboratoryofMolecularCardiology,UniversityMedicalCenteroftheJohannesGutenberg-UniversityMainz,Langenbeckstr.1,55131Mainz,Germany;2GermanCenterforCardiovascularResearch(DZHK),PartnerSiteRhine-Main,Langenbeckstr.1,55131Mainz,Germany;3InstituteofNeurosurgicalPathophysiology,UniversityMedicalCenteroftheJohannesGutenberg-UniversityMainz,Langenbeckstr.1,55131Mainz,Germany;4PreventiveCardiologyandPreventiveMedicine,CenterforCardiology,UniversityMedicalCenteroftheJohannesGutenberg-UniversityMainz,Langenbeckstr.1,55131Mainz,Germany;5InstituteofNormalandPathologicalPhysiology,SlovakAcademyofSciences,Sienkiewiczova1,81371Bratislava,Slovakia;6CenterforThrombosisandHemostasis,UniversityMedicalCenteroftheJohannesGutenberg-UniversityMainz,Langenbeckstr.1,55131Mainz,Germany;7InstituteforImmunology,UniversityMedicalCenteroftheJohannesGutenberg-UniversityMainz,Langenbeckstr.1,55131Mainz,Germany;8InstituteofNeuropathology,UniversityHospital,Schmelzbergstr.12,8091Zurich,Switzerland;9DepartmentofNeurology,UniversityMedicalCenteroftheJohannesGutenberg-UniversityMainz,Langenbeckstr.1,55131Mainz,Germany;10InstituteforMolecularGenetics,JohannesGutenbergUniversity,J.-J.-Becherweg32,55099Mainz,Germany;and11CenterforCardiology,CardiologyII-Rhythmology,UniversityMedicalCenteroftheJohannesGutenberg-UniversityMainz,Langenbeckstr.1,55131Mainz,GermanyReceived11August2017;revised20February2018;editorialdecision22May2018;accepted22May2018;online...
