ArticleRegulatoryInnateLymphoidCellsControlInnateIntestinalInflammationGraphicalAbstractHighlightsdILCregsexistinmouseandhumanintestinesdILCregscontributetotheresolutionofinnateintestinalinflammationdILCregssuppresstheactivationofILC1sandILC3sviasecretionofIL-10dAutocrineTGF-b1isrequiredfortheexpansionofILCregsduringinflammationAuthorsShuoWang,PengyanXia,YiChen,...,ZhinanYin,ZhihengXu,ZusenFanCorrespondencewangshuo@moon.ibp.ac.cn(S.W.),fanz@moon.ibp.ac.cn(Z.F.)InBriefAsubpopulationofinnatelymphoidcells,calledILCregs,arefoundtohavearegulatoryroleinintestinalhomeostasisandinnateimmunedefensesakintoTregcells.Wangetal.,2017,Cell171,201–216September21,2017ª2017ElsevierInc.http://dx.doi.org/10.1016/j.cell.2017.07.027ArticleRegulatoryInnateLymphoidCellsControlInnateIntestinalInflammationShuoWang,1,7,*PengyanXia,1,7YiChen,3YuanQu,1ZhenXiong,1BuqingYe,1YingDu,1YongTian,2,4ZhinanYin,5ZhihengXu,6andZusenFan1,2,8,*1CASKeyLaboratoryofInfectionandImmunity,CASCenterforExcellenceinBiomacromolecules,InstituteofBiophysics,ChineseAcademyofSciences,100101Beijing,China2UniversityofChineseAcademyofSciences,100049Beijing,China3DepartmentofGastrointestinalSurgery,StateKeyLaboratoryofBiotherapy,WestChinaHospital,SichuanUniversity,610041Chengdu,China4KeyLaboratoryofRNABiologyofCAS,InstituteofBiophysics,ChineseAcademyofSciences,100101Beijing,China5TheFirstAffiliatedHospital,BiomedicalTranslationResearchInstituteandGuangdongProvinceKeyLaboratoryofMolecularImmunologyandAntibodyEngineering,JinanUniversity,510632Guangzhou,China6StateKeyLaboratoryofMolecularDevelopmentalBiology,InstituteofGeneticsandDevelopmentalBiology,ChineseAcademyofSciences,100101Beijing,China7Theseauthorscontributedequally8LeadContact*Correspondence:wangshuo@moon.ibp.ac.cn(S.W.),fanz@moon.ibp.ac.cn(Z.F.)http://dx.doi.org/10.1016/j.cell.2017.07.027SUMMARYAnemergingfamilyofinnatelymphoidcells(termedILCs)hasanessentialroleintheinitiationandregula-tionofinflammation.However,itisstillunclearhowILCsareregulatedinthedurationofi...
