TheRNAexosomesyncsIAV-RNAPIItranscriptiontopromoteviralribogenesisandinfectivity.AlexanderRialdi1,JuddHultquist2,DavidJimenezMorales2,ZuleymaPeralta3,LauraCampisi1,RomainFenouil3,NatashaMoshkina1,ZhenZhenWang1,BriceLaffleur4,RobynMichael2,KelseyHaas2,EvangelosPefanis5,RandyA.Albrecht1,LarsPache6,SumitChanda6,JoannaJen7,JordiOchando8,MinjiByun8,UttiyaBasu4,AdolfoGarcia-Sastre9,NevanKrogan#2,HarmvanBakel#3,andIvanMarazzi10,11,*1DepartmentofMicrobiology,IcahnSchoolofMedicineatMountSinai,NewYork,NY10029-6574,USA2DepartmentofCellularandMolecularPharmacology,UniversityofCalifornia,SanFrancisco,SanFrancisco,CA94158-2140,USA3DepartmentofGeneticsandGenomicSciences,IcahnSchoolofMedicineatMountSinai,NewYork,NY10029-6574,USA4DepartmentofMicrobiologyandImmunology,CollegeofPhysiciansandSurgeons,ColumbiaUniversity,NewYork,NY10032,USA5RegeneronPharmaceuticalsandRegeneronGeneticsCenter,Tarrytown,NY10591,USA6BurnhamInstituteforMedicalResearch,LaJolla,CA92037,USA7DepartmentofNeurology,UniversityofCalifornia,LosAngeles,CA90095,USA8PrecisionImmunologyInstitute,IcahnSchoolofMedicineatMountSinai,NewYork,NY10029-6574,USA9DepartmentofMicrobiology,IcahnSchoolofMedicineatMountSinai,NewYork,NY10029-6574,USA;GlobalHealthandEmergingPathogensInstitute,IcahnSchoolofMedicineatMountSinai,NewYork,NY10029-6574,USA;DivisionofInfectiousDiseases,DepartmentofMedicine,IcahnSchoolofMedicineatMountSinai,NewYork,NY10029-6574,USA*Correspondence:ivan.marazzi@mssm.edu(I.M.).AUTHORCONTRIBUTIONSConceptualization,I.M.andA.R.;Methodology,I.M.andA.R.;FormalAnalysis,A.R.,Z.P.,R.F.,H.v.B.,D.J.M.,J.H.,K.H.,Z.W.;Investigation,A.R.,N.M.,B.L.,E.P.,L.C.,J.H.,K.H.,R.F.,Z.P.;Resources,J.J.,R.A.,U.B.,A.G.S.,M.B.,H.v.B.,N.K.;Writing–OriginalDraft,I.M.andA.R.;Writing–Review&Editing,I.M.andA.R.;Visualization,A.R.,J.H.,K.H.,Z.P.;Supervision,I.M.;FundingAcquisition,I.M.Publisher'sDisclaimer:ThisisaPDFfileofanuneditedmanuscriptthathasbeenacceptedforpublication.Asaservicetoourcustomersweareprovidingthisearlyversionofthemanuscrip...