TargetingGliomaStemCellsthroughCombinedBMI1andEZH2InhibitionXunJin1,2,3,LeoJ.Y.Kim1,4,5,6,QiulianWu1,6,LisaC.Wallace1,BrianaC.Prager1,4,5,6,7,TanwaratSanvoranart1,RyanC.Gimple1,4,5,6,XiuxingWang1,6,StephenC.Mack1,8,TylerE.Miller1,4,5,PingHuang1,ClaudiaL.Valentim1,Qi-gangZhou1,JillS.Barnholtz-Sloan9,ShidengBao1,7,9,AndrewE.Sloan9,10,andJeremyN.Rich1,6,7,91DepartmentofStemCellBiologyandRegenerativeMedicine,LernerResearchInstitute,ClevelandClinic,Cleveland,OH,USA2TianjinMedicalUniversityCancerInstituteandHospital,Tianjin,P.R.China3FirstAffiliatedHospitalofWenzhouMedicalUniversity,Wenzhou,Zhejiang,P.R.China4DepartmentofPathology,CaseWesternReserveUniversity,Cleveland,OH,USA5MedicalScientistTrainingProgram,SchoolofMedicine,CaseWesternReserveUniversity,Cleveland,OH,USA6DivisionofRegenerativeMedicine,DepartmentofMedicine,UniversityofSanDiego,SanDiego,CA,USA7ClevelandClinicLernerCollegeofMedicineofCaseWesternReserveUniversity,Cleveland,OH,USA8DepartmentofPediatrics,DivisionofPediatricHematologyandOncology,BaylorCollegeofMedicine,Houston,TX,USA9CaseComprehensiveCancerCenter,CaseWesternReserveUniversitySchoolofMedicine,Cleveland,OH,USA10DepartmentofNeurologicalSurgery,UniversityHospitals-ClevelandMedicalCenter,Cleveland,OH,USAAbstractUsersmayview,print,copy,anddownloadtextanddata-minethecontentinsuchdocuments,forthepurposesofacademicresearch,subjectalwaystothefullConditionsofuse:http://www.nature.com/authors/editorial_policies/license.html#termsCorrespondenceshouldbeaddressedtoJ.N.R.(drjeremyrich@gmail.com)orA.E.S.(andrew.sloan@uhhospitals.org).AuthorContributionsXJandJNRdesignedtheoverallexperiments,analyzeddata,andwrotethemanuscript.XJ,LJYK,LCW,TS,SCM,TEM,QW,PH,XW,CLV,andQZperformedcellcultureand/oranimalexperiments.XJ,LJYK,BCP,RCG,andSCMperformedbioinformaticsanalysisofpublishedexpressiondatasets.JSB-S,SB,andAESprovidedintellectualinputandpatienttissues.Allauthorsprovidedscientificinput,editedandapprovedthefinalmanuscript.COMPETINGFINANCIALINTERESTSJNRreceivedanhonorari...
