28December2018AperTO-ArchivioIstituzionaleOpenAccessdell'UniversitàdiTorinoPhosphatidylinositol3-kinaseblockadeincreasesgenomicinstabilityinBcells/Compagno,Mara;Wang,Qi;Pighi,Chiara;Cheong,Taek-Chin;Meng,Fei-Long;Poggio,Teresa;Yeap,Leng-Siew;Karaca,Elif;Blasco,RafaelB.;Langellotto,Fernanda;Ambrogio,Chiara;Voena,Claudia;Wiestner,Adrian;Kasar,SiddhaN.;Brown,JenniferR.;Sun,Jing;Wu,CatherineJ.;Gostissa,Monica;Alt,FrederickW.;Chiarle,Roberto.-In:NATURE.-ISSN0028-0836.-542:7642(2017),pp.483-493.OriginalCitation:Phosphatidylinositol3-kinaseblockadeincreasesgenomicinstabilityinBcellsPublishedversion:DOI:10.1038/nature21406Termsofuse:OpenAccess(Articlebeginsonnextpage)Anyonecanfreelyaccessthefulltextofworksmadeavailableas"OpenAccess".WorksmadeavailableunderaCreativeCommonslicensecanbeusedaccordingtothetermsandconditionsofsaidlicense.Useofallotherworksrequiresconsentoftherightholder(authororpublisher)ifnotexemptedfromcopyrightprotectionbytheapplicablelaw.Availability:Thisisapreprintversionofthefollowingarticle:Thisversionisavailablehttp://hdl.handle.net/2318/1634221since2017-05-15T15:38:46ZPhosphatidylinositol3-Kinase(PI3K)δblockadeincreasesgenomicinstabilityinBcellsMaraCompagno1*,QiWang1*,ChiaraPighi1*,Taek-ChinCheong1,Fei-LongMeng2,6,TeresaPoggio3,Leng-SiewYeap2,7,ElifKaraca1,RafaelB.Blasco1,FernandaLangellotto1,8,ChiaraAmbrogio4,ClaudiaVoena1,3,AdrianWiestner5,SiddhaN.Kasar4,JenniferR.Brown4,JingSun4,CatherineJ.Wu4,MonicaGostissa2,8,FrederickW.Alt2andRobertoChiarle1,31DepartmentofPathology,Children’sHospitalBostonandHarvardMedicalSchool,Boston,MA,02115USA2HowardHughesMedicalInstitute,PrograminCellularandMolecularMedicine,BostonChildren’sHospital,andDepartmentofGenetics,HarvardMedicalSchool,Boston,MA02115,USA3DepartmentofMolecularBiotechnologyandHealthSciences,UniversityofTorino,Torino,10126Italy4DepartmentofMedicalOncology,Dana-FarberCancerInstitute,HarvardMedicalSchool,Boston,MA02115,USA5HematologyBranch,NationalHeart,Lung,andBloodInstitute,Bethesda,MD6Presentaddre...
