ArticleHumanPancreaticbCelllncRNAsControlCell-SpecificRegulatoryNetworksGraphicalAbstractHighlightsdAloss-of-functionscreenrevealsfunctionalbcelllncRNAsdCell-specificlncRNAsandtranscriptionfactorsregulatecommongenenetworksdThelncRNAPLUTOinfluencesinteractionsbetweenanenhancerclusterandPDX1dPLUTOandPDX1arederegulatedintype2diabetesandimpairedglucosetoleranceAuthorsIldemAkerman,ZhidongTu,AnthonyBeucher,...,EricSchadt,PhilippeRavassard,JorgeFerrerCorrespondencejferrerm@imperial.ac.ukInBriefAkermanetal.studiedthefunctionofhumanbcelllncRNAswithRNAi,CRISPRi,andco-expressionnetworks.ThisrevealedbcelllncRNAsandtranscriptionfactorsthatcontrolcommonregulatorynetworks.OnelncRNA,PLUTO,isdownregulatedintype2diabetesandcontrolsPDX1,encodingakeybcelltranscriptionfactor.AccessionNumbersGSE83619Akermanetal.,2017,CellMetabolism25,400–411February7,2017ª2016PublishedbyElsevierInc.http://dx.doi.org/10.1016/j.cmet.2016.11.016CellMetabolismArticleHumanPancreaticbCelllncRNAsControlCell-SpecificRegulatoryNetworksIldemAkerman,1,2,3ZhidongTu,4AnthonyBeucher,1DelphineM.Y.Rolando,1ClaireSauty-Colace,5MarionBenazra,5NikolinaNakic,1JialiangYang,4HuanWang,4LorenzoPasquali,3,6IgnasiMoran,1JavierGarcia-Hurtado,2,3NataliaCastro,2,3RoserGonzalez-Franco,1AndrewF.Stewart,7CarolineBonner,8LorenzoPiemonti,9ThierryBerney,10LeifGroop,11JulieKerr-Conte,8FrancoisPattou,8CarmenArgmann,4EricSchadt,4PhilippeRavassard,5andJorgeFerrer1,2,3,12,*1SectionofEpigenomicsandDisease,DepartmentofMedicine,ImperialCollegeLondon,LondonW120NN,UnitedKingdom2GenomicProgrammingofBetaCellsLaboratory,Institutd’InvestigacionsBiomediquesAugustPiISunyer(IDIBAPS),Barcelona08036,Spain3CentrodeInvestigacio´nBiome´dicaenReddeDiabetesyEnfermedadesMetabo´licasAsociadas(CIBERDEM),Madrid28029,Spain4DepartmentofGeneticsandGenomicScience,IcahnSchoolofMedicineatMountSinai,NewYork,NY10029,USA5SorbonneUniversite´s,UPMCUnivParis06,INSERM,CNRS,Institutducerveauetdelamoelle(ICM)–HoˆpitalPitie´-Salpeˆtrie`re,Boulevarddel’Hoˆpital,Paris...
