FTOplaysanoncogenicroleinacutemyeloidleukemiaasaN6-methyladenosineRNAdemethylaseZejuanLi1,7,10,HengyouWeng1,2,10,RuiSu2,10,XiaochengWeng3,8,10,ZhixiangZuo1,2,9,10,ChenyingLi2,4,HuilinHuang2,SigridNachtergaele3,LeiDong2,ChaoHu1,2,4,XiQin2,LichuanTang5,YunguiWang1,2,4,Gia-MingHong1,HaoHuang1,XiaoWang3,PingChen1,SandeepGurbuxani6,StephenArnovitz1,YuanyuanLi1,ShenglaiLi1,JenniferStrong2,MaryBethNeilly1,RichardA.Larson1,XiJiang1,2,PuminZhang5,JieJin4,ChuanHe3,*,andJianjunChen1,2,11,*1SectionofHematology/Oncology,DepartmentofMedicine,UniversityofChicago,Chicago,IL60637,USA2DepartmentofCancerBiology,UniversityofCincinnatiCollegeofMedicine,Cincinnati,OH45219,USA3DepartmentofChemistry,DepartmentofBiochemistryandMolecularBiology,InstituteforBiophysicalDynamics,HowardHughesMedicalInstitute,UniversityofChicago,Chicago,IL60637,USA4KeyLaboratoryofHematopoieticMalignancies;DepartmentofHematology,TheFirstAffiliatedHospitalZhejiangUniversity,Hangzhou,Zhejiang310003,China5DepartmentofMolecularPhysiologyandBiophysics,BaylorCollegeofMedicine,Houston,TX77030,USA6DepartmentofPathology,UniversityofChicago,Chicago,IL60637,USA7DepartmentofHumanGenetics,UniversityofChicago,Chicago,IL60637,USA*Correspondence:chuanhe@uchicago.edu;chen3jj@ucmail.uc.edu.10Theseauthorscontributedequallytothiswork11LeadContactPublisher'sDisclaimer:ThisisaPDFfileofanuneditedmanuscriptthathasbeenacceptedforpublication.Asaservicetoourcustomersweareprovidingthisearlyversionofthemanuscript.Themanuscriptwillundergocopyediting,typesetting,andreviewoftheresultingproofbeforeitispublishedinitsfinalcitableform.Pleasenotethatduringtheproductionprocesserrorsmaybediscoveredwhichcouldaffectthecontent,andalllegaldisclaimersthatapplytothejournalpertain.ACCESSIONNUMBERSThemicroarray,m6A-seqandRNA-seqdatahavebeendepositedintheGeneexpressionOminibus(GEO)repositorywiththeaccessionnumbersGSE34184,GSE30285,GSE76414,GSE84944andGSE85008.SUPPLEMENTALINFORMATIONSupplementalInformationincludesSupplementalExperimentalProcedures,FiguresandT...
