ArticleChemoresistanceEvolutioninTriple-NegativeBreastCancerDelineatedbySingle-CellSequencingGraphicalAbstractHighlightsdSingle-cellsequencingofbreastcancerpatientstreatedwithchemotherapydPatientsshowedclonalpersistenceorextinctioninresponsetotherapydResistanceoccurredthroughadaptiveselectionofpre-existinggenomicaberrationsdChemotherapyinducedtranscriptionalreprogrammingofresistantsignaturesAuthorsCharissaKim,RuliGao,EmiSei,...,NicolaCrosetto,TheodorosFoukakis,NicholasE.NavinCorrespondencetheodoros.foukakis@ki.se(T.F.),nnavin@mdanderson.org(N.E.N.)InBriefCombinationofsingle-cellDNAandRNAsequencingdepictstheevolutionarytrajectoriesofchemoresistanceinhumantriple-negativebreastcanceratthegenomicandtranscriptomiclevel,highlightingthepresenceofpre-existinggenomicalterationsandtranscriptionalreprogrammingofresistantsignatures.Kimetal.,2018,Cell173,879–893May3,2018ª2018ElsevierInc.https://doi.org/10.1016/j.cell.2018.03.041ArticleChemoresistanceEvolutioninTriple-NegativeBreastCancerDelineatedbySingle-CellSequencingCharissaKim,1,2,6RuliGao,1,6EmiSei,1RachelBrandt,1JohanHartman,3ThomasHatschek,3NicolaCrosetto,4TheodorosFoukakis,3,*andNicholasE.Navin1,2,5,7,*1DepartmentofGenetics,UTMDAndersonCancerCenter,Houston,TX77030,USA2GraduateSchoolofBiologicalSciences,UTMDAndersonCancerCenter,Houston,TX77030,USA3DepartmentofOncology-Pathology,KarolinskaInstitute,SE-17176Stockholm,Sweden4DepartmentofMedicalBiochemistryandBiophysics,KarolinskaInstitute,SE-17177Stockholm,Sweden5DepartmentofBioinformaticsandComputationalBiology,UTMDAndersonCancerCenter,Houston,TX77030,USA6Theseauthorscontributedequally7LeadContact*Correspondence:theodoros.foukakis@ki.se(T.F.),nnavin@mdanderson.org(N.E.N.)https://doi.org/10.1016/j.cell.2018.03.041SUMMARYTriple-negativebreastcancer(TNBC)isanaggres-sivesubtypethatfrequentlydevelopsresistancetochemotherapy.Anunresolvedquestioniswhetherresistanceiscausedbytheselectionofrarepre-existingclonesoralternativelythroughtheacquisi-tionofnewgenomicaberrations.Toinve...
