ArticleNKCellsStimulateRecruitmentofcDC1intotheTumorMicroenvironmentPromotingCancerImmuneControlGraphicalAbstractHighlightsdNKcellsrecruitcDC1intothetumormicroenvironmentdcDC1recruitmentdependsonNKcell-derivedchemokinesCCL5andXCL1dTheNKcell/chemokine/cDC1axisisassociatedwithcancerpatientsurvivaldTumor-derivedPGE2impairsNKcellandcDC1resultingincancerimmuneevasionAuthorsJanP.Bo¨ttcher,EduardoBonavita,ProbirChakravarty,...,ErikSahai,SantiagoZelenay,CaetanoReiseSousaCorrespondencej.boettcher@tum.de(J.P.B.),caetano@crick.ac.uk(C.R.e.S.)InBriefNaturalkillercellsrecruitdendriticcellstothetumormicroenvironment,anddisruptionofthisprocessresultsincancerimmuneevasion.ImmunecontrolImmuneescapeXCL1CCL5NKcellscDC11PGE2XCL1CCL5COX1/2COX-deficienttumorCOX-sufficienttumorXCL1CCLBo¨ttcheretal.,2018,Cell172,1022–1037February22,2018ª2018FrancisCrickInstitute.PublishedbyElsevierInc.https://doi.org/10.1016/j.cell.2018.01.004ArticleNKCellsStimulateRecruitmentofcDC1intotheTumorMicroenvironmentPromotingCancerImmuneControlJanP.Bo¨ttcher,1,5,*EduardoBonavita,2ProbirChakravarty,3HannaBlees,1MarCabeza-Cabrerizo,1StefanoSammicheli,1NeilC.Rogers,1ErikSahai,4SantiagoZelenay,2andCaetanoReiseSousa1,6,*1ImmunobiologyLaboratory,TheFrancisCrickInstitute,1MidlandRoad,LondonNW11AT,UK2CancerInflammationandImmunityGroup,CRUKManchesterInstitute,TheUniversityofManchester,ManchesterM204BX,UK3Bioinformatics,TheFrancisCrickInstitute,1MidlandRoad,LondonNW11AT,UK4TumourCellBiologyLaboratory,TheFrancisCrickInstitute,1MidlandRoad,LondonNW11AT,UK5Presentaddress:InstituteofMolecularImmunologyandExperimentalOncology,KlinikumMu¨nchenrechtsderIsar,TechnischeUniversita¨tMu¨nchen,Ismaningerstr.22,81675Mu¨nchen,Germany6LeadContact*Correspondence:j.boettcher@tum.de(J.P.B.),caetano@crick.ac.uk(C.R.e.S.)https://doi.org/10.1016/j.cell.2018.01.004SUMMARYConventionaltype1dendriticcells(cDC1)arecrit-icalforantitumorimmunity,andtheirabundancewithintumorsisassociatedwithimmune-mediatedrejectionandthesuccessofimmunothera...
