1OptimizeNormalFlowFiltrationProcesses:优化优化优化优化常规常规常规常规过滤过滤过滤过滤工艺工艺工艺工艺：：：：Selectfiltersforafiltrationprocessapplication针对过滤针对过滤针对过滤针对过滤工艺工艺工艺工艺应用应用应用应用，，，，选择过滤器选择过滤器选择过滤器选择过滤器0.22µm12345---ECUST默克密理博制药工艺开发部王斌MilliporeTraining-OptimizeNormalFlowFiltrationProcessesCopyright©2009MilliporeCorporation.Allrightsreserved.PresentationOverview演示报告综述演示报告综述演示报告综述演示报告综述�HowaFilterWorks�过滤器怎样工作�KeyMembraneandDepthFilterCharacteristics�膜式和深层过滤器关键特性�TypicalFiltrationFormats�典型过滤格式�FilterFoulingMechanisms�过滤器堵塞机理�IntroductiontoFilterSizingandScalingModels�过滤器尺寸分析和缩放模型介绍2MilliporeTraining-OptimizeNormalFlowFiltrationProcessesCopyright©2009MilliporeCorporation.Allrightsreserved.CellCulture/PurificationFilterOperations细胞培养细胞培养细胞培养细胞培养/纯化过滤器操作纯化过滤器操作纯化过滤器操作纯化过滤器操作CellCultureMediaPrep细胞培养基制备Fermentation发酵CellHarvest细胞收获ProteinPurification蛋白质纯化FinalFilling最终灌装ViralClearance病毒清除MilliporeTraining-OptimizeNormalFlowFiltrationProcessesCopyright©2009MilliporeCorporation.Allrightsreserved.NFFApplicationsNFF应用应用应用应用TankVents罐通气CellCultureMedia细胞培养基FermenterAir发酵罐空气ClarificationNFF澄清NFFBuffers缓冲液FinalFilling最终灌装VirusRemoval病毒去除3HowaFilterWorks过滤器怎样工作过滤器怎样工作过滤器怎样工作过滤器怎样工作MilliporeTraining-OptimizeNormalFlowFiltrationProcessesCopyright©2009MilliporeCorporation.Allrightsreserved.MicroporousMembranes微孔膜UltrafiltrationMembranes超滤膜ReverseOsmosisMembranes反渗透膜VirusMembranes病毒膜4MilliporeTraining-OptimizeNormalFlowFiltrationProcessesCopyright©2009MilliporeCorporation.Allrightsreserved.�Adsorption�吸附•Attractionforcesbetweenparticlesandfiltermaterial•颗粒与过滤材料之间的吸引力•Molecularand/orelectrical•分子和/或电吸附•Notsize-dependent•与尺寸无关与尺寸无关与尺寸...
