胶原海绵在慢性下肢溃疡中应用临床疗效观察魏庆1任伟业2张晶3李晨3姚昶3*摘要目的：评价胶原海绵促进下肢慢性溃疡愈合的临床疗效及相关作用机制方法：将40例下肢慢性溃疡患者分为治疗组和对照组，每组各20例。治疗组给予以胶原海绵覆盖创面，对照组给予以凡士林纱布覆盖创面，疗程为4周。分别于治疗后2周、4周采用照相法计算创面愈合率；治疗后1周、2周、4周评价疮面肉芽积分。结果：治疗组创面愈合率治疗后4周高于对照组，差异有统计学意义；疮面肉芽积分在2周与4周时达到统计学差异（P<0.05或0.01）。结论：胶原海绵可以促进慢性下肢溃疡肉芽生长，提高慢性疮面愈合率。关键词：胶原海绵，慢性疮面，愈合，肉芽Clinicalobservationofenhancingwoundhealingwithcollagenspongeapplicationonchroniclegulcerfor20patientsAbstractObject:Toevaluatetheclinicaleffectsofcollagenspongeapplicationonchroniclegulcerandexplorethepossiblerelationshipwithimprovingthegrowthofgranulationsofwound.Methods:40patientsofchroniclegulcerswereincludedintheresearch,halfofwhichisforexperimentgroupwiththelocaladministrationofcollagenspongeandtheotherhalfisforthecontrolwiththelocaladministrationofpetrolatumgauze.Theappearancesofgranulationtissueswereevaluatedasscoresforthedatesof1-week,2-weekand4-week.Thewoundsurfacehealingratesevaluatedbyelectronicwoundmedicalrecordsystemwererecordedforthedatesof2-weekand4-week.Results:Theratesofwoundsurfacehealingandtheappearancesofgranulationtissueswerehigherwithexperimentalgroupthanthoseofcontrolgroupatdatesof4-weekand2-weektogetherwith4-weekrespectivelywithstatisticdifferences(P<0.05or0.01).Conclusions:Collagenspongeisabletoimprovewoundhealingwhichmaybyonewayofincreasethegrowthofwoundgranulations.Keywords:Collagensponges,chroniculcer,woundhealing,granulation疮面愈合过程延长，最终导致解剖和功能的缺陷，可以形成慢性难愈性疮面[1]，简称慢性疮面。临床上一般认为6-8周未愈合的疮面即可称为慢性疮面[2]。目前在临床上治疗非常困难，现代多以手术为主治疗。手术创伤给患者造成进一步痛苦，且如果疮面较大，手术无法达到预期目的，而其他的新技术疗效有待进一步验证。胶原是细胞外基质的主要成分，应用于创面，组织相容性好、同时直接提供创面营...
