PRISMA-P(PreferredReportingItemsforSystematicreviewandMeta-AnalysisProtocols)2015checklist:recommendeditemstoaddressinasystematicreviewprotocol*SectionandtopicItemNoChecklistitemReportedonPage#ADMINISTRATIVEINFORMATIONTitle:Identification1aIdentifythereportasaprotocolofasystematicreviewUpdate1bIftheprotocolisforanupdateofaprevioussystematicreview,identifyassuchRegistration2Ifregistered,providethenameoftheregistry(suchasPROSPERO)andregistrationnumberAuthors:Contact3aProvidename,institutionalaffiliation,e-mailaddressofallprotocolauthors;providephysicalmailingaddressofcorrespondingauthorContributions3bDescribecontributionsofprotocolauthorsandidentifytheguarantorofthereviewAmendments4Iftheprotocolrepresentsanamendmentofapreviouslycompletedorpublishedprotocol,identifyassuchandlistchanges;otherwise,stateplanfordocumentingimportantprotocolamendmentsSupport:Sources5aIndicatesourcesoffinancialorothersupportforthereviewSponsor5bProvidenameforthereviewfunderand/orsponsorRoleofsponsororfunder5cDescriberolesoffunder(s),sponsor(s),and/orinstitution(s),ifany,indevelopingtheprotocolINTRODUCTIONRationale6DescribetherationaleforthereviewinthecontextofwhatisalreadyknownObjectives7Provideanexplicitstatementofthequestion(s)thereviewwilladdresswithreferencetoparticipants,interventions,comparators,andoutcomes(PICO)METHODSEligibilitycriteria8Specifythestudycharacteristics(suchasPICO,studydesign,setting,timeframe)andreportcharacteristics(suchasyearsconsidered,language,publicationstatus)tobeusedascriteriaforeligibilityforthereviewInformationsources9Describeallintendedinformationsources(suchaselectronicdatabases,contactwithstudyauthors,trialregistersorothergreyliteraturesources)withplanneddatesofcoverageSearchstrategy10Presentdraftofsearchstrategytobeusedforatleastoneelectronicdatabase,includingplannedlimits,suchthatitcouldberepeatedStudyrecords:Datamanagement11aDescribethemechanism(s)thatwillbeusedtomanagerecordsanddatathroughoutthereviewSelectionprocess11bStatetheprocessthatwillbeusedfor...