FORMATANDSTYLEManuscriptsshouldbewritteninclear,grammaticalEnglish,typeddouble-spaced,andallpagesmustbenumbered.ManuscriptsthatarenotinAACRstyleorthatarenotingoodidiomaticEnglishmaybereturnedtotheauthorwithoutreview.FortheconvenienceofauthorswhosenativelanguageisnotEnglish,wehaveprovidedalistofeditingandproofreadingservicesforscientificmanuscriptsinourAuthorServicesCenter.Laboratoryjargonaswellasterminologyandabbreviationsnotconsistentwithinternationallyacceptedguidelinesshouldbeavoided.TheAACRjournalsgenerallyconformtousageguidelinesinScientificStyleandFormat:TheCSEManualforAuthors,Editors,andPublishers(SeventhEdition,2006,publishedbytheCouncilofScienceEditors,Reston,VA).Forgeneralguidanceonmanuscriptpreparation,consultthedocumentsissuedbytheInternationalCommitteeofMedicalJournalEditors.Manuscriptsshouldbearrangedinthefollowingorder:titlepage,textandreferences,tables,legendsforalltablesandfigures,figures.Seebelowforfullexplanationofwhatistobeincludedinthesesections.Seealsoeachjournal'sinstructionsforexceptionstothesegeneralinstructions.WhensubmittingmanuscriptsthatincludeSupplementaryData,pleasebesuretouploadsupplementalfilesseparately,intheappropriateareaofthesubmissionform(SeealsothedetailedpoliciesonpreparationofSupplementaryData).Pleasedonotappendsupplementalfilestothemainmanuscriptfile.Numberedandletteredsectionsinthetextshouldbeavoided.Eachtableandillustrationmustbecitedinorderinthetext.Simplechemicalformulasormathematicalequationsshouldbepresentedinaformthatallowstheirreproductioninsinglehorizontallinesoftype;morecomplicatedmathematicalformulasorchemicalstructuresdifficulttosetintypeshouldbeprovidedforreproductionintheformoflinedrawings,glossyphotographs,ordigitalfiles.TitlepageTitle.Writeabrief,informativetitle.Abbreviationsshouldnotbeusedintitles.Itisimportantforliteratureretrievaltoincludeinthetitlethekeywordsthatidentifythenatureofthesubjectmatter,including,ifapplicable,thespeciesonwhichtheworkisdone.Authorsandaffiliations.Authorsareurgedtoincludethei...