[Date][JournalEditor’sname(firstnamefollowedbyfamilyname)][Editor’stitle,JournalNameinitalics,titlecase][Journal’sfullpostaladdress]DearDr.[Editor’sfamilyname],Onbehalfofallauthors,Iwouldliketoaskyoutoconsiderourmanuscriptentitled“addmanuscripttitlewithinthequotationmarksusingsentencecase”forpublicationin[JournalNameinitalics,titlecase]asanoriginalresearcharticle.This[addtypeofstudyifrelevant,suchasprospectivecohort,randomizedcontrolledtrial,double-blind,multicenter]studyinvestigated[addtheresearchproblemthatyousoughttoanswer],focusingon[addprimaryendpoint].Ifrelevant,addthefollowingsentence:Allstudyparticipantsprovidedinformedconsent,andthestudydesignwasapprovedbyanethicsreviewboard.[Addasentencedescribingthebackgroundorreasonsfordoingthestudy.]Here,conciselydescribethemainresultsandsignificantconclusions.Webelievethatfindingsfromthisstudywillbeofspecialinteresttothereadersof[addJournalName].Explainwhyyourfindingswillberelevanttoreadersofthejournal,consideringthejournal’saimsandscopeandtheimplicationsofyourstudy.Withoutwishingtotakealiberty,mycoauthorsandIwouldliketosuggestthreepotentialreferees:Dr.[A,institution,address,phone,e-mail]Dr.[B,institution,address,phone,e-mail]Dr.[C,institution,address,phone,e-mail][Addanydisclosurestatementsorinformationpertainingtoethicalstandardsrequiredbythejournal.]Thismanuscripthasnotbeenpublishedandisnotunderconsiderationforpublicationelsewhere.Alltheauthorshaveapprovedthemanuscriptandagreewiththissubmission.Sincerely,[Submittingauthor’sfullnameanddegree,suchasPhD;MD,PhD;MD,DMedSc][Submittingauthor’sinstitution][Fullpostaladdress][Telephonenumber;E-mailaddress]
