CoverLetter范例3Deareditor（最好确定编辑姓名）,Themanuscriptentitled“XXX”waspreparedfollowingtheinstructionsforauthorsofACSNano.Theoriginalresearchishelpfultothosewhoareinterestedinbiocompatibilityevaluationsonpharmaceuticalexcipientsanddrugdeliverysystems,especiallythosebasedonnatural/syntheticmacromoleculesandpolymericnanoparticles(NPs)（阐述的主要受众）.Inourpreviouswork,anovelchitosanderivate,XXXwasdevelopedandappliedasdeliveryvehiclesforanticancerdrugs,whichshoweddesiredtherapeuticefficacyforpaclitaxelasamodeldrug（本文是延续性研究，先简述前一篇文章的工作）.ThepresenceofabundantreactivecarboxylandaminogroupsinXXXofferopportunitiesforchemicalmodificationwithfunctionalligands,thusachievingtargeteddeliverytospecifictissuesandtumors.Theamphiphilic***NPsarealsocapableofsolubilizingmanypoorwater-solubledrugs,andshowgreatpotentialfordeliveringgenedrugs（提出本研究的对象和其应用价值）.Consideringtheirefficacyandpotentialapplications,ithighlightedtheneedtoperformasystematicbiocompatibilitystudyonthe***NPstoguaranteethebiologicalsafetyinuse.Therefore,thebloodcompatibility,invitrocytotoxicityandgenotoxicityevaluationswereperformed（本文研究的主要内容和意义）.Inthepresentstudy,***NPsdisplayedprolongedplasmarecalcificationtimeandimprovedanticoagulationpotentialinthedynamicbloodclottingtest.Inabatteryofcytotoxicityassaysin###and###cellsthatwasrelatedtodifferentaspectsofcelldamage,***NPsinducedminimallossofcellmembraneintegrity,cellviability,lysosomalaswellasmetabolicactivities.Althoughariseincellularmalondialdehyde(MDA)contentandadepletionofreducedglutathioneweredetectedafterexposureto***NPsatlmg/mLfor12h,noapparentsignsofDNAdamageorearlyapoptosisweredetectedfromthecometassayandflowcytometryassay.Insummary,thesafetyevaluationsprovidedpersuasiveevidencesforthedesiredbiocompatibilityof***NPswhichfavoredtheirfurtherpharmaceuticalapplications.Nowthemanuscriptissubmittedonline,andIlookforwardtohearingfromyou.SincerelyyoursXXX,Ph.D.,Prof.DepartmentofXXX,XXXUniversity,Shanghai200433,CHINAPhone:+86-21-########Fax:+86-21-########E-mail:
