·综述·促红细胞生成素在心血管手术中应用的研究进展王文婷刘晋萍DOI:10.12089/jca.2023.01.018基金项目:国家自然科学基金(81960669);中国医学科学院临床与转化医学研究基金(2020-I2M-C&T-B-063)作者单位:100037中国医学科学院北京协和医学院国家心血管病中心阜外医院体外循环中心通信作者:刘晋萍,Email:liujinping@fuwai.com【摘要】心血管手术患者具有病情危重、合并症多,异体输血率高等特点。在血制品供需不平衡的前提下,异体输血可增加患者术后并发症。促红细胞生成素在心血管手术围术期应用具有明显的优势,有望为心血管手术围术期患者提供更好的血液和器官保护管理。本文就促红细胞生成素在心血管手术围术期临床应用价值和局限性的最新进展进行综述,为临床医师在心血管手术围术期患者使用促红细胞生成素提供参考。【关键词】促红细胞生成素;心血管手术;异体输血;血液保护ResearchprogressoferythropoietininpatientsundergoingcardiovascularsurgeryWANGWenting,LIUJinping.DepartmentofCardiopulmonaryBypass,StateKeyLaboratoryofCardiovascularDisease,FuwaiHospital,NationalCenterforCardiovascularDiseases,ChineseAcademyofMedicalSciencesandPekingUnionMedicalCollege,Beijing100037,ChinaCorrespondingauthor:LIUJinping,Email:liujinping@fuwai.com【Abstract】Cardiovascularsurgerypatientshavethecharacteristicsofmorecriticaldisease,morecomorbidities,andhigherallogeneicbloodtransfusionrate.Underthepremiseofimbalancebetweensupplyanddemandofbloodproducts,allogeneicbloodtransfusioncanincreasetheincidenceofpostoperativecom-plicationsandeconomicburdeninpatients.Inrecentyears,withthecontinuousexplorationoftheadvantagesoferythropoietinintheperioperativeperiodofcardiovascularsurgery,itisexpectedtoprovidebetterbloodmanagementforpatientsintheperioperativeperiodofcardiovascularsurgery.Thispaperreviewstherecentadvanceintheclinicalvalueandlimitationsoferythropoietinintheperioperativeperiodofcardio-vascularsurgeryandprovidesareferenceforclinicianstouseerythropoietinintheperioperativeperiodofcardiovascularsurgery.【Keywords】Erythropoietin;Cardiovascularsurgery;Allogeneicbloodtransfusion;Bloodprotection心血管手术通常需要在全系统...