2023年2月第30卷第2期达比加群酯对急性心肌梗死并发心房颤动患者凝血功能和预后的影响吴海燕，唐玲军（长沙市中医医院／长沙市第八医院检验科，湖南长沙410100）【摘要】目的探讨达比加群酯对急性心肌梗死（AMI）并发心房颤动患者凝血功能和预后的影响。方法280例AMI并发心房颤动患者随机分为两组。除给予相同基础治疗外，对照组给予华法林，观察组给予达比加群酯。比较两组治疗前后的凝血功能指标和预后。结果治疗后，观察组的PT、INR、TT、APTT均高于对照组，FIB低于对照组（P＜0．05）。两组的少量出血和大量出血发生率比较，差异无统计学意义（P＞0．05）；但观察组的血栓栓塞形成率、轻微出血发生率和心肌梗死再发生率均低于对照组（P＜0．05）。结论达比加群酯治疗AMI并发心房颤动可提高抗凝有效性，降低血栓栓塞、出血和心肌再梗死发生率。【关键词】急性心肌梗死；心房颤动；达比加群酯；凝血功能；预后中图分类号：R542.2+2文献标识码：Adoi:10.3969/j.issn.1674-4659.2023.02.0189ImpactofDabigatranEtexilateonCoagulationFunctionandPrognosisofPatientswithAcuteMyocardialInfarctionCom-plicatedwithAtrialFibrillation//WUHaiyan,TANGLingjun(ClinicalLaboratory,ChangshaHospitalofTraditionalChineseMedicine/ChangshaEighthHospital,Changsha410100,China)[Abstract]ObjectiveToexploretheimpactofdabigatranetexilateoncoagulationfunctionandprognosisofpatientswithacutemyocardialinfarction(AMI)complicatedwithatrialfibrillation.Methods280patientswithAMIcomplicatedwithatrialfibrillationwererandomlydividedintotwogroups.Inadditiontothesamebasictreatment,thecontrolgroupwasgivenwarfarin,andtheobservationgroupwasgivendabigatranetexilate.Thecoagulationfunctionindicatorsbeforeandaftertreatment,andtheprognosiswerecomparedbetweenthetwogroups.ResultsAftertreatment,PT,INR,TTandAPTTintheobservationgroupwerehigherthanthoseinthecontrolgroup,andFIBwaslowerthanthatinthecontrolgroup(P<0.05).Nosignificantdifferencewasfoundintheincidencesofminorbleedingandmassivebleedingbetweenthetwogroups(P>0.05);However,thethromboembolismformationrate,incidenceofslightbleedingandrecurrencerateofmyocardialinfarctionintheobservationgroupwerelowerthanthoseinthecontrolgroup(P<0.05).Conclu...
